This investigation studies the impact of trace elements supplementation on protein anaerobic conversion into volatile fatty acids (VFAs). Two continuous reactors were operated with two model substrates, casein and gelatin, at acid (pH 5) neutral 7) conditions, addition macro micronutrients. Micronutrients increased acidification degree both proteins from 40% to 50% more than 60% only pH 7, whic...

Combretastatin A-4 (CA-4) is a naturally occurring microtubular-destabilising agent that possesses potent anti-tumour and anti-vascular properties both in vitro and in vivo. Clinical trials to date indicate that its water-soluble prodrug, combretastatin A-4 phosphate (CA-4P), is well tolerated at therapeutically useful doses. However, the stilbenoid structure of CA-4, consisting of two phenyl r...

BACKGROUND The amyloid-β (Aβ) peptide is the primary component of the extracellular senile plaques characteristic of Alzheimer's disease (AD). The metals hypothesis implicates redox-active copper ions in the pathogenesis of AD and the Cu(2+) coordination of various Aβ peptides has been widely studied. A number of disease-associated modifications involving the first 3 residues are known, includi...

SIR,-Dr Weitz and colleagues (April 20, p 933) report the value of breath pentane analysis as an index of increased lipid peroxidation in vivo. However, Weitz et al fail to indicate the potential shortcomings of the method, as we are beginning to see in the context of cystic fibrosis. We have found that techniques involving hydrocarboncontaminated inspired air, as used by Weitz et al, produce u...

The ultrafast Z→E and E→Z photoisomerisation dynamics of 5,6-dihydrodibenzo[c,g][1,2]diazocine (1), the parent compound of a class of bridged azobenzene-based photochromic molecular switches with a severely constrained eight-membered heterocyclic ring as central unit, have been studied by femtosecond time-resolved spectroscopy in n-hexane as solvent and by quantum chemical calculations. The dia...

Dietary lycopene consists mostly of the (all-E) isomer. Upon absorption, (all-E) lycopene undergoes isomerisation into various (Z)-isomers. Because these isomers offer potentially better health benefits than the (all-E) isomer, the aim of the present study was to investigate if the profile of lycopene isomers in intestinal lipoproteins is affected by the profile of lycopene isomers in the meal ...

Isomerisation kinetics of the 9c11t and 10t12c Conjugated Linoleic Acids (CLA) in triaclglycerols at isothermal conditions (250, 280 and 325 o C) has been studied by infrared spectroscopy. Fifteen micro liter portions of the glycerides were placed in micro glass ampoules and sealed under nitrogen. Several glass tubes containing the same triacylglycerols were then subjected to thermal treatment....