OBJECTIVE The purpose of the present study was to validate various surrogate estimates of insulin sensitivity (IS) in a renal transplant population and to assess the influence of immunosuppressive and antihypertensive therapy on insulin resistance (IR) after renal transplantation. RESEARCH DESIGN AND METHODS A total of 167 consecutive renal transplant recipients without previously known diabe...

Data from neurons in vivo have shown that spike output can often sustain episodes of high variability. Theoretical studies have indicated that the high conductance state of neurons brought on by synaptic activity can contribute to an increase in the variability of spike output by decreasing the integration timescale of the neuron. In the present work, we were interested in understanding how bac...

AIMS To evaluate an easier alternative method to orthogonal regression analysis for calculating International Sensitivity Indexes (ISI). METHODS ISI for 18 reagents were estimated from reference and test reagent prothrombin times using plasma from 60 stabilised patients undergoing anticoagulation therapy and 20 normal subjects. ISI were also derived for 12 systems (instrument/reagent combinat...

neuromelanin (nm) pigment accumulates with age in catecholaminergic neurons in man, and the ventral substantia nigra dopaminergic neurons that are the most vulnerable to degeneration in parkinson's disease (pd) contain the greatest amount of this pigment. in vitro data indicate that nm pigment is formed from the excess cytosolic catecholamine that is not accumulated into synaptic vesicles via t...