We performed extensive neuropsychological assessment of two male patients (matched for age and educational level) with similar (localization and size) unilateral paramedian ischemic thalamic lesions (AB on the left and SD on the right). Both patients showed severe memory impairments as well as other cognitive deficits. In comparison to SD, AB showed severe impairment of executive functions and ...

We report the case of a 40-year-old right-handed German-speaking man who presented with ischemic stroke in the territories of the right superior cerebellar artery and posterior inferior cerebellar artery. The objective of the present study was to investigate the consequences of this cerebellar damage with regard to higher cognitive functions. On admission to the stroke unit, the patient present...

Epigenetic regulation of neuronal signalling through histone acetylation dictates transcription programs that govern neuronal memory, plasticity and learning paradigms. Histone Acetyl Transferases (HATs) and Histone Deacetylases (HDACs) are antagonistic enzymes that regulate gene expression through acetylation and deacetylation of histone proteins around which DNA is wrapped inside a eukaryotic...

background:  gender  difference  has  been   reported  in stroke  risk factors  and  disease  history. the aim  of this study  was  to  compare  risk factors  and  the  severity  of ischemic stroke based  upon  modified rankin scale (mrs) and hospital mortality between two genders. methods: in a  cross-sectional  study, 341  patients  (44% males and 56% females with a mean age of 68.94 ± 12.74 ...

background: serum trace element alteration has been reported in dilated and ischemic cardiomyopathy. the reports were controversial. we have studied serum zinc level in cardiomyopathy patients in northern province of mazandaran and compared them with healthy volunteers. methods: serum zinc level was measured in 30 ischemic and 18 dilated cardiomyopathy patients against 27 healthy volunteers. it...

For decades, lactic acid has been considered a dead-end product of glycolysis. Research in the last 20+ years has shown otherwise. Through its transporters (MCTs) and receptor (GPR81), lactic acid plays a key role in multiple cellular processes, including energy regulation, immune tolerance, memory formation, wound healing, ischemic tissue injury, and cancer growth and metastasis. We summarize ...

Background: Stroke is the third leading cause of mortality worldwide. One of the factors that affect the occurrence of stroke can be attributed to changes in the levels of trace elements. Accumulating evidence has been shown that magnesium, as an important element, is a new predictor of stroke. We aimed to determine the levels of Mg in ischemic stroke patients in comparison with those having th...