AIMS To evaluate the prevalence and the independent prognosis of electrocardiographic left ventricular hypertrophy by voltage only, ST depression and negative T wave, isolated negative T wave and left ventricular hypertrophy plus ST depression and negative T wave for cardiac morbidity and mortality, without known ischaemic heart disease at baseline. METHODS AND RESULTS Follow-up data from the...

OBJECTIVE To examine associations between milk consumption and incident heart disease and stroke. DESIGN A representative population sample of men was asked to weigh and record their food intake for seven days. The total consumption of milk was obtained from these records. Details of all deaths and vascular events were collected during the following 20 years. Incident ischaemic strokes and he...

This study shows that the Q wave pattern on the electrocardiogram provides insufficient evidence for the diagnosis of ischaemic heart disease. Apparent evidence of ischaemic heart disease on the electrocardiogram was misleading in 6 out of zo patients with congestive cardiomyopathy and in 3 of 8 patients with hypertrophic cardiomyopathy. With the increasing application of surgical techniques to...

BACKGROUND The aetiology of idiopathic dilated cardiomyopathy is believed to have an immunological component. Association with human leucocyte antigens (HLAs) has been previously reported, particularly with HLA-DR4. AIM To determine the association of HLA type with diagnosis in a group of patients assessed for heart transplantation. METHODS A comparison was made of frequencies of HLA types ...

Heart disease is a leading cause of death worldwide. In many forms of heart disease, including heart failure, ischaemic heart disease and diabetic cardiomyopathies, changes in cardiac mitochondrial energy metabolism contribute to contractile dysfunction and to a decrease in cardiac efficiency. Specific metabolic changes include a relative increase in cardiac fatty acid oxidation rates and an un...

Correspondence to: Don Poldermans, MD, PhD, Thoraxcentre, Department of Cardiology, Erasmus Medical Centre Rotterdam, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands; [email protected] _________________________ C oronary artery disease is the most common cause of congestive heart failure. More than 70% of the patients with heart failure symptoms have underlying coronary diseas...

Correspondence to: Don Poldermans, MD, PhD, Thoraxcentre, Department of Cardiology, Erasmus Medical Centre Rotterdam, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands; [email protected] _________________________ C oronary artery disease is the most common cause of congestive heart failure. More than 70% of the patients with heart failure symptoms have underlying coronary diseas...

A newly developed, highly sensitive immunoassay for creatine kinase MB isoenzyme was evaluated in 68 patients with or without different types of ischaemic heart disease. Patients were classified on the basis of clinical criteria in four groups: no ischaemic heart disease, stable angina, unstable angina, and acute myocardial infarction. Enzyme concentration in patients with stable angina was the...

A cardiovascular study of a group of 90 newly diagnosed diabetic women aged 35 to 75 years was begun in 1965 and a repeat examination was carried out on the same patients in 1968. A high prevalence of ischaemic heart disease was found in these patients at the time of diagnosis, and this finding had some predictive value as regards prognosis over the three-year period.A comparative study with ge...