Central MessageAdvanced cardiac imaging provides ever-increasing amounts of data on congenital heart disease. Practical application these by surgeons is not always straightforward.See Article page 196. Advanced straightforward. See anatomic and physiologic As with many things in life, more better. To surgeons, are better when they inform our decision making thus improve surgical outcomes. Shen ...

In the recent issue of Cell, Bonham et al. (2014) reveal that the sorting adaptor TIRAP regulates the assembly of the Myddosome upon Toll-like receptor activation from both the cell surface and endosomes through its promiscuous binding to lipids.