As an essential nutrient element for life, iron’s metabolic balance in body tissues is crucial to sustaining normal physiological functions, and it inextricably related tumors. Nanotechnology gaining much attention around the world cancer treatment. Considering critical role of iron metabolism, nanocarriers’ toxicity biocompatibility, novel nanomaterials based on biochemical activity regulatory...

Metals are ubiquitous and play a critical role in neurobiology. Transition metals are important because they alter the redox state of the physical environment. Biologically, transition metals catalyze redox reactions that are critical to cellular respiration, chemical detoxification, metabolism, and even neurotransmitter synthesis. Many metals are both nutrients and neurotoxicants, such as iron...

HD patients, or its accumulation due to renal failure, logically inhibits the iron release by macrophages, limiting its availability for erythropoiesis [4] . In accordance with the negative correlation between prohepcidin and hematocrit are the findings of Dallalio et al. [5] , who in a recent in vitro study detected that hepcidin can contribute to anemia not only through an effect on iron meta...

Iron is essential for normal cellular homeostasis but in excess promotes free radical formation and is detrimental. Therefore, iron metabolism is tightly regulated. Here, we show that mechanisms regulating systemic iron metabolism may also control iron release into the brain at the blood-choroid plexus-cerebrospinal fluid (CSF) barrier. Intraperitoneal administration of lipopolysaccharide (LPS)...

It is well-known that deficiency or over exposure to various elements has noticeable effects on human health. The effect of an element is determined by several characteristics, including absorption, metabolism, and degree of interaction with physiological processes. Iron is an essential element for almost all living organisms as it participates in a wide variety of metabolic processes, includin...

The two iron regulatory proteins IRP1 and IRP2 bind to transcripts of ferritin, transferrin receptor and other target genes to control the expression of iron metabolism proteins at the post-transcriptional level. Here we compare the effects of genetic ablation of IRP1 to IRP2 in mice. IRP1-/- mice misregulate iron metabolism only in the kidney and brown fat, two tissues in which the endogenous ...