We investigated the relation between maternal anaemia and neonatal iron status in 97 mothers and their babies. Haemoglobin (Hb), serum iron, total iron binding capacity and serum ferritin were determined. Mothers were divided into 3 groups: iron-deficient anaemic (22.7%), non-anaemic iron-deficient (27.8%) and non-anaemic non-iron-deficient (49.5%). There was no significant difference in the me...

BACKGROUND Plasma non-transferrin bound iron refers to heterogeneous plasma iron species, not bound to transferrin, which appear in conditions of iron overload and ineffective erythropoiesis. The clinical utility of non-transferrin bound iron in predicting complications from iron overload, or response to chelation therapy remains unproven. We undertook carefully timed measurements of non-transf...

Regular packed cell transfusion in patients with thalassemia major leads to iron overload. Chelation therapy is one of the important aspects of thalassemia care as iron overload causes significant cardiac, hepatic, and endocrine dysfunction. We report a case of thalassemia major with severe iron overload causing cardiac and liver dysfunction who benefitted from triple drug chelation therapy. Tr...

Iron is an essential but potentially hazardous biometal. Mammalian cells require sufficient amounts of iron to satisfy metabolic needs or to accomplish specialized functions. Iron is delivered to tissues by circulating transferrin, a transporter that captures iron released into the plasma mainly from intestinal enterocytes or reticuloendothelial macrophages. The binding of iron-laden transferri...

The iron-regulatory hormone hepcidin is a 25-amino acid peptide that is synthesized in hepatocytes. Hepcidin binds to the cellular iron export channel ferroportin and causes its internalization and degradation and thereby decreases iron efflux from iron exporting tissues into plasma. By this mechanism, hepcidin inhibits dietary iron absorption, the efflux of recycled iron from splenic and hepat...

Given its potential toxicity and low bioavailability, iron metabolism in humans is a tightly regulated process. Two main levels of regulation have been described: a cellular regulation that, through the binding of iron-responsive proteins (IRPs) to iron-responsive elements in mRNA from genes encoding proteins of iron metabolism, controls the synthesis of transferrin receptor (necessary for cell...

background: iron chelators are an important part of management of patients with thalassemia. it is prudent to compare efficacy of different iron chelators in treatment of iron overload in these patients who receive regular blood transfusion. we aimed to compare the efficacy and safety of available oral iron chelator; deferasirox (exjade®) with deferasirox (osveral®) in reducing iron overload in...

in this study the iron status of pregnant women in two different socio-economic groups and also the effect of multigravidity on iron status of the mothers were investigated. blood samples were with drawn from 165 mothers (91 from farah and 74 from missaghieh maternity hospital) immediately after delivery and hemoglobin, hematocrit, serum iron, total iron-binding capacity (tibc) and total protei...

Iron deficiency is prevalent in children and infants worldwide. Zinc deficiency may be prevalent, but data are lacking. Both iron and zinc deficiency negatively affect growth and psychomotor development. Combined iron and zinc supplementation might be beneficial, but the potential interactions need to be verified. In a randomized, placebo-controlled trial using 2 x 2 factorial design, 609 Thai ...

OBJECTIVE : To determine the impact of contaminant iron and geophagy on iron intake and status of persons living in developing countries. DESIGN : Literature for review was identified by searching Medline and Agricola, from appropriate other texts and from three reports from the Opportunities for Micronutrient Interventions (OMNI) Project of USAID. SETTING : The dietary intake of iron by pe...