Recently, mutations causing juvenile hemochromatosis have been identified in a novel gene, hemojuvelin (HJV), located on chromosome 1. Mouse models of this disease have now been developed by 2 groups, Huang et al. and Niederkofler et al., through targeted disruption of the Hjv gene (see the related articles beginning on pages 2180 and 2187). These mutant mice will allow further investigation in...

OBJECTIVE To examine intellectual and motor functioning of children who received micronutrient supplementation from 12 to 35 months of age. DESIGN Cohort follow-up of children 7 to 9 years of age who participated in a 2 × 2 factorial, placebo-controlled, randomized trial from October 2001 through January 2006. SETTING Rural Nepal. PARTICIPANTS A total of 734 children 12 to 35 months of ag...

Women of reproductive age are at a high risk of iron deficiency, often as a result of diets low in bioavailable iron. In some settings, the iron content of domestic groundwater sources is high, yet its contribution to iron intake and status has not been examined. In a rural Bangladeshi population of women deficient in dietary iron, we evaluated the association between groundwater iron intake an...

OBJECTIVE To determine the prevalence of anemia and iron status among Chilean women of childbearing age between 1981 and 2010. MATERIALS AND METHODS Calculation of the prevalence of anemia and iron status was based on multiple cross-sectional iron absorption studies performed in 888 women during this period of time. All studies included measurements of hemoglobin, mean corpuscular volume, zin...

SYMPOSIUM PROCEEDINGS I967 during late foetal development and the amount of folate in the liver. However, the mean birth weight of Asians is less than that of English babies born in Bradford and at all gestational ages the individual birth weights of Asians were nearly always relatively low; there was a relatively high proportion of Asian babies in which the amount of iron in the liver was smal...

The brain uses iron for many essential processes (1-4). The extent of iron utilization is heavily dependent on local functional requirements, leading to significant variations in tissue iron concentrations throughout the brain (5-7). This was graphically illustrated nearly a century ago in the first colour illustrations of the differential distribution of iron throughout the brain architecture,...