Introduction: Brachytherapy, especially using manually after loaded Iridium-192 and Cobalt-60, can be applied as a sole treatment, as a treatment complementary to surgery, and as a local boost in combination with EBRT. The use of HDR brachytherapy catheters incorporated in removable dental molds allows repeated, highly reproducible, fractionated outpatient brachytherapy of supe...

Using nanoparticles for controlled drug delivery to cancer, in response its weakly acidic environment, represents a promising approach toward increasing the effectiveness and reducing adverse effects of cancer therapy. Hence, aim this study is construct novel mesoporous silica nanoparticle (MSN)-based acidification-responsive systems targeted Herein, surface MSN covalently functionalized with I...

Biscyclometalated iridium(III) complexes with an ancillary acetylacetone ligand, Ir(L)(2)(acac), (L = 2-(benzo[b]thiophen-2-yl)pyridine (btp), 1-phenylisoquinoline (piq), 2-phenylbenzothiazole (bt), 2-phenylpyridine (ppy), acac = deprotonated acetylacetone), demonstrate spectroscopic changes in their UV-Vis absorption and luminescent emission under acidic conditions. Such changes were found to ...

Cyclometalated iridium complexes have important applications as phosphorescent probes for cellular imaging due to their photophysical properties. Moreover, these properties also make them potential candidates as photosensitizers for photodynamic therapy (PDT) of tumors and skin diseases. Treatment of MCF7 breast carcinoma cells with a heteroleptic phosphorescent cyclometalated iridium(III) comp...

Needle-shaped crystals of the metal-rich phosphide Ce4Ir13.55P9 were synthesized from the elements in a lead flux (starting composition 1 : 2 : 2 : 60) at 1370 K followed by slow cooling. Ce4Ir13.55P9 crystallizes with a new orthorhombic structure type: Pnma, a = 1269.1(2), b = 399.1(1), c = 3349.9(7) pm, wR2 = 0.0722, 2025 F2 values and 139 variables. Two of the 14 crystallographic iridium sit...