Article type: Original article Objective(s): Calcineurin (CN) is a main phosphatase and a critical regulator of cellular pathways for learning, memory, and plasticity. The FK-506 (tacrolimus), a phosphatase inhibitor, is a fungalderived agent and a common immune suppressant extensively used for tissue transplantation. To further clarify the role of CN in different stages of learning and memory ...

Article type: Original article Objective(s): Occludin is essential for proper assembly of tight junctions (TJs) which regulate paracellular endothelial permeability. Omega-3 polyunsaturated fatty acids (Ω-3 PUFA) protect endothelial barrier function against injury. Materials and Methods: We examined anti-inflammatory effect of Ω-3 PUFA intake (30 mg/kg/day for 10 days) on expression and locatio...

he interest in using and conducting clinical trials in developing world is rising promptly. Knowing the importance of this kind of research in generating therapeutic evidence, many clinical researchers in developing countries including Iran are getting involved in performing clinical trials. Authors performed a quick search in ISI Web of Knowledge database (May 2008) which shows interesting res...

Adolescence is an important stage of human life span, which crucial developmental processes occur. Since peers play a critical role in the psychosocial development of most adolescents, peer education is currently considered as a health promotion strategy in adolescents. Peer education is defined as a system of delivering knowledge that improves social learning and provides psychosocial support....

CONTEXT All over the the world, preterm birth is a major cause of death and important neurodevelopmental disorders. Approximately 9.6% (12.9 million) births worldwide are preterm. EVIDENCE ACQUISITION In this review, databases such as PubMed, EMBASE, ISI, Scopus, Google Scholar and Iranian databases including Iranmedex, and SID were researched to review relevant literature. A comprehensive se...

BACKGROUND Health-related quality of life (HRQoL) measurement in elderly people can provide appropriate information for an optimal management of physical/mental conditions. The main objective of the present study was to quantitatively assess the HRQoL among healthy elder Iranian individuals as measured by the Short-Form 36 (SF-36) questionnaire, both overall and at the level of each its single ...

Dünyada nükleer reaktörlerde kazaların meydana gelmesinden sonra, daha güvenli ısı çekimini sağlayan sistemler kullanılmaya başlanmıştır. Bunlardan biri de pasif güvenlik sistemi olan borulu reaktördür. Isı boruları kullanılırken en önemli konulardan limitasyonlarının belirlenmesidir. Bu makalede 900 K’de çalışan reaktörde limitasyonları hesaplanmıştır. borusunun çalışma sıvıları olarak potasyu...

1Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, IR Iran 2Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, IR Iran 3Shiraz HIV/AIDS Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran 4Department of Epidemiology and Biostatistics, School of Public ...

BACKGROUND Students' perceptions of the educational environment are an important construct in assessing and enhancing the quality of medical training programs. Reliable and valid measurement, however, can be problematic - especially as instruments developed and tested in one culture are translated for use in another. MATERIALS AND METHOD This study sought to explore the psychometric propertie...