BACKGROUND The aim of this study was to evaluate the effects of remote ischemic preconditioning (RIPC) and dexmedetomidine as pharmacological conditioning in a rat renal ischemia/reperfusion (IR) injury model. METHODS Total of 28 male Wistar Albino rats weighing 250 to 300 g were divided into 4 equal groups. Group I (Sham; n=7): Laparotomy and renal pedicle dissection were performed, and the ...

BACKGROUND Remote ischemic preconditioning (RIP) and pharmacological preconditioning are the effective methods that can be used to prevent ischemia reperfusion (IR) injury. The aim of this study was to evaluate the effects of RIP and N-Acetylcysteine (NAC) with RIP in the rat hepatic IR injury model. MATERIALS AND METHODS 28 rats were divided into 4 groups. Group I (sham): only laparotomy was...

eart failure is a progressive, chronic disorder. Insulin resistance (IR) has been more and more involved as a preliminary metabolic perturbance predisposing to hyperglycemia, hyperlipidemia and atherosclerosis with others heart diseases. To investigate the relation of insulin resistance (IR) in non-diabetic heart failure patients this case-control study was carried out to ascertain the presence...

Previous studies have demonstrated that depletion of Gas7 impedes neurite outgrowth in primary cultures of Purkinje neurons, and that Gas7 promotes neurite outgrowth in PC12 cells. To investigate the physiological function of Gas7, we generated by homologous recombination a Gas7-mutant mouse which produced a Gas7 variant protein with an in-frame deletion of amino acid residues 103–120. Only low...

Ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) gene has been studied in relation to type 2 diabetes mellitus (T2DM) and insulin resistance (IR). We hypothesized that the difference in genotype may be one of the factors that affect the outcome of intervention. We genotyped 448 men with fasting glucose≥5.6 mM/L, including 371 in subjects with K allele (KK) (69 control group [CG];...

CONTEXT Pathologies such as anterior instability and impingement are common in baseball and have been linked to decreases in internal-rotation (IR) motion and concurrent increases in external-rotation (ER) motion. In addition, alterations to scapular upward rotation have been identified in this population. OBJECTIVE To measure glenohumeral (GH) IR and ER rotation, total range of motion (ROM),...

BACKGROUND Ischemia-reperfusion (IR) injury is seen in many settings such as free flap salvage and limb replantation/revascularization. The consequences-partial/total flap loss, functional muscle loss, or amputation-can be devastating. Of the treatment options available for IR injury, hyperbaric oxygen (HBO) is the most beneficial. HBO inhibits neutrophil-endothelial adhesion through interferen...

BACKGROUND Dry mouth is known to cause severe pain in the intraoral structures, and many dry mouth patients have been suffering from intraoral pain. In development of an appropriate treatment, it is crucial to study the mechanisms underlying intraoral pain associated with dry mouth, yet the detailed mechanisms are not fully understood. To evaluate the mechanisms underlying pain related to dry m...