Guite and colleagues recently attempted to identify risk factors for certain causes of death among patients admitted to hospital with asthma. The data were originally collected for a diVerent purpose, however, and problems of data quality and completeness limit the conclusions that can be drawn from this analysis. The current study is based on follow up of 2242 (68%) of the original cohort of 3...

BACKGROUND & OBJECTIVES Asthma is now regarded as an inflammatory disease and bronchial inflammation may disrupt mucociliary function. Inhaled drugs may act by improving mucociliary function. The aim of the study was to investigate the effect of salbutamol, ipratropium bromide and beclomethasone on mucociliary clearance in patients with chronic stable asthma and to compare the efficacy of these...

Guite and colleagues recently attempted to identify risk factors for certain causes of death among patients admitted to hospital with asthma. The data were originally collected for a diVerent purpose, however, and problems of data quality and completeness limit the conclusions that can be drawn from this analysis. The current study is based on follow up of 2242 (68%) of the original cohort of 3...

We investigated whether salbutamol (S) and ipratropium bromide (IB) exerted a true additive bronchodilator effect in asthma. In fifteen selected chronic asthmatics, individual cumulative dose-response curves to S and IB were performed on two separate days (linear regression of bronchodilator response (delta FEV1) between 20 and 80% of maximal response, versus log dose), and the dose of S equipo...

BACKGROUND In acute asthma the optimal duration of treatment with combination beta agonist and anticholinergic nebuliser solutions is unknown; most studies have investigated single doses or treatment for up to 12 hours. To determine whether longer treatment with ipratropium bromide might aid recovery a study was undertaken in 106 patients with acute asthma. METHODS A double blind, randomised,...

PURPOSE Relative costs and utilization-related outcomes of a fluticasone propionate 250 μg + salmeterol 50 μg combination (FSC), tiotropium bromide, and ipratropium as initial maintenance therapy in COPD have not been compared in a commercially-insured population. METHODS This retrospective, observational cohort study used health care claims data from January 2004 to June 2009 from a large ad...

It has been suggested that in normal subjects inhaled anticholinergic agents have a preferential dilating effect on large central airways. We therefore studied 21 patients with asthma to see if response to inhaled ipratropium bromide was related to the initial central or peripheral site of major airway narrowing. Fourteen out of 21 patients with asthma increased their Vmax more than 10% after i...

Guite and colleagues recently attempted to identify risk factors for certain causes of death among patients admitted to hospital with asthma. The data were originally collected for a diVerent purpose, however, and problems of data quality and completeness limit the conclusions that can be drawn from this analysis. The current study is based on follow up of 2242 (68%) of the original cohort of 3...