Collective evidence indicates that motor neuron degeneration in amyotrophic lateral sclerosis (ALS) is non-cell-autonomous and requires the interaction with the neighboring astrocytes. Recently, we reported that a subpopulation of spinal cord astrocytes degenerates in the microenvironment of motor neurons in the hSOD1(G93A) mouse model of ALS. Mechanistic studies in vitro identified a role for ...

We show that activation of postsynaptic inositol 1,4,5-tris-phosphate receptors (IP(3)Rs) with the IP(3)R agonist adenophostin A (AdA) produces large increases in AMPA receptor (AMPAR) excitatory postsynaptic current (EPSC) amplitudes at hippocampal CA1 synapses. Co-perfusion of the Ca(2+) chelator bis-(o-aminophenoxy)-N,N,N',N'-tetraacetic acid strongly inhibited AdA-enhanced increases in EPSC...

promotion of the dietary fiber of foods can enhance human health by reducing the risk of many serious diseases. cakes are among the highly consumed foods but sadly of low fiber content. therefore, increasing the fiber content in them is of great importance, and this was the aim followed in this study. wheat flour was partially replaced at 0, 10, 20 and 30% (w/w) with corn resistant starch (rs),...

in this study, an attempt has been made to expound the iranian law of intellectual property in relation to biotechnology. the most important themes studied are patents, industrial designs and trade marks. the latest relevant piece of legislation concerning the subject matters was passed in march 2008. however, the history of laws and regulations in this field goes back to early twentieth centur...

OXFORD, England — British P rim e M in is te r Tony B la ir ’s a n n o u n c e m e n t of re -e le c tio n April 5, with the election to be held May 5, has complicated the P a rlia m e n ta ry in te rn s h ip s of N otre Dam e London s tu d e n ts this term , according to cu rren t in te rn s and th e in te rn s h ip ad m in is tra to rs . W hile P a r lia ­ m ent has been disso lved and in ter...

Abstract Background and Aims: IP-10 molecule is a new biomarker to predict response to treatment in chronic HCV infection. Also urine IP-10 has been suggested as a biomarker in other infections. But already, it has low data in urine as well as serum level of IP-10 for HCV infection. The aim of this study was to assess urine and serum level of IP-10 in patients with type 1 and 3a HCV infect...

simultaneous dislocation of both interphalangeal (ip) joints of same finger is a highly uncommon finding. and dislocation of metacarpophalangeal (mcp) joint along with interphalangeal joints of thumb are reported in literatures if, scarcely. here we are reporting the three cases, comprising of double dislocation of ip joints in little finger in two patients and simultaneous mcp and ip joint dis...

The Rotating-Stall (RS) through a rotor-cascade of an axial compressor were numerically investigated with an unsteady two-dimensional finite-volume density based computer code. To validate the computer code, a test case was prepared and the good agreement of the compared results has given the adequate assurance of the code. The RS was incepted with a 40% reduction in flow coefficient and a 0.4%...