particularpH owing to the screening ofthe haematin iron atom from the influence of the various ionizing groups. On this basis a larger critical I would signify that a larger concentration of salt ions is required for complete screening, and hence that there is a stronger interaction between the iron and the ionizing groups in MetHb. In conclusion, although the mechanism may be different it may ...

Deinococcus radiodurans is among a small number of bacterial species that are extremely resistant to ionizing radiation, UV light, toxic chemicals, and desiccation. We measured proteome oxidation (i.e., protein carbonylation, PC) in D. radiodurans as well as in standard and evolved resistant strains of Escherichia coli exposed to ionizing radiation or UVC light and found a consistent correlatio...

Physics is the science that studies the interaction between matter and energy. This discipline studies the general properties of bodies, the forces that modify the transfer of energy and the interaction between particles. Physics now has many branches, and one of them is the Biomedical Physics. Biomedical Physics in Medicine applies the principles and methods of physics. This will generate new ...

As diversity in amphibian species declines, the search for causes has intensified. Work in this area has shown that amphibians are especially susceptible to the combination of heightened UVB radiation and increased nitrate concentrations. Various astrophysical events have been suggested as sources of ionizing radiation that could pose a threat to life on Earth, through destruction of the ozone ...

PURPOSE We aimed to detect the expression of HIF-1α, VEGF, HPSE-1 and CD31 in SKOV3 xenografts in nude mice treated with different doses of ionizing radiation, trying to explore the possible mechanism of hypoxia and radioresistance. METHODS Nude mice bearing SKOV3 xenografts were randomly divided into 4 groups: Group A (control group, no ionizing radiation), Group B (treated with low dose of ...

Through various researches and investigations it has been established that high doses of ionizing radiation are harmful to health. There is substantial controversy regarding the effects of low doses of ionizing radiation despite the large amount of work carried out (both laboratory and epidemiological). According to the linear no-threshold (LNT) hypothesis, any amount, however small, of radiati...

Trypanosoma cruzi, the causative agent of Chagas disease, is extremely resistant to ionizing radiation, enduring up to 1.5 kGy of gamma rays. Ionizing radiation can damage the DNA molecule both directly, resulting in double-strand breaks, and indirectly, as a consequence of reactive oxygen species production. After a dose of 500 Gy of gamma rays, the parasite genome is fragmented, but the chrom...

The tumor suppressor p53 plays an essential role in cellular adaptation to stress. In response to ionizing radiation, p53 regulates the transcription of genes in a diverse set of pathways including DNA repair, cell cycle arrest, and apoptosis. Previously, we identified by microarray analysis a set of genes that are transcriptionally activated or repressed in response to radiation exposure. In t...