The Zweifel olefination is a powerful method for the stereoselective synthesis of alkenes. The reaction proceeds in the absence of a transition-metal catalyst, instead taking place by iodination of vinyl boronate complexes. Pioneering studies into this reaction were reported in 1967 and this short review summarizes developments in the field over the past 50 years. An account of how the Zweifel ...

From the §Division of Endocrinology, Department of Internal Medicine, !Protein and Nucleic Acid Research Facility and Department of Microbiology, University of Virginia School of Medicine, Charlottesville, Virginia 22908 and the $Departamento de Endocrinologia Experimental, Instituto de Znvestigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas, and Facultad de Medicina, Univer...

Regulatory activity has been demonstrated in two classes of iodinated organic species: thyroid hormones (T(3) and T(4)) and iodinated lipids (ILs), e.g. 6-iodo-5-hydroxy-8,11,14-eicosatrienoic acid. The formation of iodinated biomolecules requires iodide oxidation. In mammals iodide oxidation is one of several peroxidase-mediated reactions that serve to reduce hydrogen peroxide. I(2) is one of ...

The composition and disposition of the constituent polypeptides of rat cerebral cortical synaptosomal membranes were analyzed on SDS acrylamide gels. Of 20 bands readily detected, 11 account for greater than 93% of the total protein analyzed. These are: (molecu25); 3 (175); 4 (doublet, 137); 5 (doublet, 97); 6 (68); 7 (61); 8 (54); 9 (44); 10 (37); and 11 (33). Bands 5 and 8-10 are the most pro...