We present an innovative methodology for the sustained delivery of hydrophobic drugs using composite hydrogels, prepared by embedding oil-in-water microemulsions in hydrophilic hydrogels. The hydrophobic nature of the microemulsion core enhances the solubilization of hydrophobic drugs, while the crosslinked matrix could be readily used as a solid controlled delivery vehicle. A microemulsion was...

This study aimed at designing mucoadhesive microemulsion gel to enhance the brain uptake of Ibuprofen through intranasal route. Ibuprofen loaded mucoadhesive microemulsion (MMEI) was developed by incorporating polycarbophil as mucoadhesive polymer into Capmul MCM based optimal microemulsion (MEI) and was subjected to characterization, stability, mucoadhesion and naso-ciliotoxicity study. Brain ...

In this study the effect of temperature, NaCl and oils (hydrocarbons: C(8)-C(16)) on the formation and solubilization capacity of the systems of oil/monoacylglycerols (MAG):ethoxylated fatty alcohols (CEO(20))/propylene glycol (PG)/water was investigated. The effects of the surfactant mixture on the phase behavior and the concentration of water or oil in the systems were studied at three temper...

Objective: The aim of this study was to investigate the effects of intravenous magnesium sulfate on the prevention of pain during the injection of microemulsion propofol. Magnesium is a known calcium channel blocker and a physiological N-methyl-D-aspartate receptor antagonist. Methods: American Society of Anesthesiologists I and II adults (n= 114) undergoing general anesthesia for surgery were ...

To formulate a compatible green medium for the conversion of a hydrophobic substrate by a hydrophilic enzyme, we investigated the phase behavior of pseudo ternary hydrophobic ionic liquid (HIL)/buffer/polyoxyethylene-type nonionic surfactant (CnEm)/n-alcohol system and the effects of the components on the formulation of the HIL-based bicontinuous microemulsion. It is found that small head group...

We examined the intradermal delivery of a hydrophilic polyphenol chlorogenic acid by in vitro study using excised guinea pig dorsal skin and Yucatan micropig skin. Skin accumulation as well as the solubility of chlorogenic acid in aqueous vehicles was much greater than for other polyphenols such as quercetin and genistein. However, since enhancement of skin delivery seemed to be necessary to ex...

short timeframe, and rapid approaches are needed to assess log Pow values of these compounds (2,4,7). Several separation-based approaches for indirectly determining log Pow values in a rapid fashion have been reported, including reversed-phase high performance liquid chromatography (HPLC) (2,3,8–11), thin-layer chromatography (12,13), micellar electrokinetic chromatography (MEKC) (7,14–16), and...

We recall briefly the knowledge on microemulsion structure emphasizing the importance of the surfactant layer properties. We present results of experiments made with water-alkanenon-ionic surfactants systems that, together with results obtained earlier in other systems, confirm the close relationship between the maximum characteristic size in the microemulsion and the persistence length of the ...

The aim of this study was to develop suitable microemulsion gel systems for transdermal delivery that could assist dissolution enhancement of poorly water soluble celecoxib and thus improve its skin permeability. Long term oral administration of celecoxib causes serious gastrointestinal adverse effects, which makes it a good candidate for transdermal formulations, yet its low water solubility (...