Screening is a public health activity to detect disease among people thought a priori to be well. In the United States, the major cervical screening target is treatable CIN3 (or, to be especially cautious, CIN2), not invasive cervical cancer, for which treatment causes far more morbidity and is less certain to succeed. Therefore, cervical screening distinguishes between the few women who might ...

PURPOSE Among invasive ductal carcinomas of the pancreas (IDCP), there is a morphologically characteristic subgroup accompanied by abundant intraductal carcinoma components (ICCs). With the aim of determining whether ICC-rich IDCP are biologically different from ICC-poor IDCP, the expression status of Dpc4 protein was analyzed. EXPERIMENTAL DESIGN A total of 43 IDCP was subdivided into two gr...

OBJECTIVE To determine factors influencing long term risks for acquiring or dying from invasive cervical or vaginal cancer in women previously treated for cervical intraepithelial neoplasia grade 3 (CIN3). DESIGN Population based cohort study conducted in 1958-2008, followed up until 2009 in the Swedish Cancer Registry and Swedish Cause of Death Register, linked to the Swedish Population Regi...

If left untreated, a subset of high-grade squamous intraepithelial lesions (HSIL) of the cervix will progress to invasive squamous cell carcinomas (SCC). To identify genes whose differential expression is linked to cervical cancer progression, we compared gene expression in microdissected squamous epithelial samples from 10 normal cervices, 7 HSILs, and 21 SCCs using high-density oligonucleotid...

UNLABELLED Cell cycle protein expression plays an important role in the pathophysiology of cervical cancer. However, few studies have attempted to correlate the use of these biomarkers with the clinical progression of the tumor. OBJECTIVES 1) To analyze the expression of Ki-67, p53 and p16(INK4a) in cervical cancer, 2) to correlate the relative expression of these proteins as well as clinical...

ecause cervical cancer has few subjective symptoms, and progression to invasive cancer is slow, early detection of precancerous lesions by screening is important for prevention. It is globally acknowledged that the prevalence of cervical cancer screening as a secondary prevention is effective for reducing the incidence of cervical cancer and mortality. However, adherence with the recommended sc...

PURPOSE The purposes of the study were (1). to assess the cost-effectiveness of three interventions to deliver breast and cervical cancer screening to women unscreened for >or=3 years and (2). to determine the relation of an invasive cervical cancer diagnosis to the interval since the last true screening test. METHODS In a randomized trial, women were randomly assigned to (1). usual care, (2)...

BACKGROUND The association between HIV infection and invasive cervical cancer that has been reported may reflect differential prevalence of human papillomavirus (HPV) infection or uncontrolled confounding. We conducted a case-control study in a West African population to assess the relationship between HIV infection and invasive cervical cancer, taking into account HPV infection and other poten...

AIM To determine the prevalence of high-grade cervical lesion (CIN 2 or worse, CIN 2+) and the prevalence of invasive cancers in women with LSIL, HSIL and positive for malignancy on cytology, respectively. METHODS A retrospective study of patients undergoing colposcopy in Rajavithi hospital between 2003-2004 was performed. The final diagnosis was based on colposcopy and histology. RESULTS A...

UNLABELLED Clarifying the diagnosis of clinically suspected recurrence of cervical cancer can be challenging. The aim of this study was to investigate the clinical value of (18)F-FDG PET in this context. METHODS The medical records of a cohort of 40 (18)F-FDG PET referrals in whom recurrence of cervical cancer was clinically suspected were reviewed. Two expert gynecologic oncologists assessed...