Aspergillus species (Fig. 1) are conidia-forming fungi that are responsible for a wide spectrum of human illnesses. About 19 species of Aspergillus have been documented as agents of human disease, but the majority of infections are caused by Aspergillus fumigates (Fresenius, 1850), Aspergillus flavus (Link,1809), Aspergillus niger (Van Tieghem, 1867), and Aspergillus terreus (Thom, 1918) [1, 2]...

background and purpose: chronic granulomatous disease (cgd) is an inherited disorder of the nicotinamide adenine dinucleotide phosphate (nadph) oxidase complex. this disorder results in recurrent life-threatening bacterial and fungal infections. aspergillus species are the most common fungal infections in these patients. case report: herein, we present a case of fungal infection in a girl with ...

We evaluated the usefulness of PCR and antigen detection for the diagnosis of pulmonary aspergillosis. Forty-four serum samples from patients with pulmonary aspergillosis (33 with pulmonary aspergilloma, 4 with allergic bronchopulmonary aspergillosis, 4 with invasive pulmonary aspergillosis, and 3 with aspergillus pyothorax) were used in this study. PCR detection of Aspergillus DNA in serum sam...

A prospective study was conducted in 38 patients with nodular lesions on plain chest radiographs and the clinical suspicion of invasive pulmonary aspergillosis (IPA) to assess the diagnostic accuracy of magnetic resonance imaging (MRI) and computed tomography (CT). For early diagnosis of IPA (clinical signs and symptoms <10 days), CT scans with demonstration of the halo sign had a high sensitiv...

INTRODUCTION Invasive pulmonary aspergillosis (IPA) is an important cause of morbidity and mortality in a wide range of patients. Early recognition and diagnosis have become a major focus in improving the management and outcomes of this life-threatening disease. BACKGROUND IPA typically occurs during a period of severe and prolonged neutropenia. However, solid organ transplant recipients, pat...

SummaryWe present a case of disseminated invasive aspergillosis in a young male adult with progressive complex gastrointestinal, non-specific peripheral neural and respiratory symptoms and subsequent acute haemorrhagic conjunctivitis and generalized dermatitis.The case emphasizes the difficulty in diagnosing systemic mycosis and a high index of suspicion is recommended particularly in patients ...

1nvasive pulmonary aspergillosis (IPA) is a necrotizing pneumonitis caused by several Aspergillus species. IPA is characterized by hyphal proliferation in the pulmonary parenchyma and by mycotic invasion of the pulmonary vasculature, with resultant hemorrhagic infarction. Aspergillosis is a disease of “medical progress” and is the second most common invasive mycosis in immunocompromised hosts (...

conclusions the incidence of ipa in allogeneic hsct and patients with hematological malignancies was relatively high and a. flavus was the most common cause of pa. as molecular methods had higher sensitivity, it may be useful as screening methods in hsct and patients with hematological malignancies, or to determine when empirical antifungal therapy can be withheld. results seven (15.2%) out of ...

Abstract Invasive aspergillosis is a dangerous infection commonly affecting immunocompromised patients. The spores of the fungal pathogen, Aspergillus, are found ubiquitously in environment and inhaled daily by all humans. These cleared quickly effectively healthy hosts without developing infection. On other hand, patients with impaired immunity, can develop an invasive pneumonia poor outcomes....