نتایج جستجو برای: invariant natural killer t cells
تعداد نتایج: 2390302 فیلتر نتایج به سال:
Summary Immunity in the human respiratory tract is provided by a diverse range of tissue-resident cells, including specialized epithelial and macrophage populations network innate innate-like lymphocytes, such as natural killer lymphoid invariant T cells. Lung-resident memory B cells contribute to this following initial exposure antigenic stimuli. This review explores how advances stud...
Although invariant NKT (iNKT) cells participate in many aspects of immune responses, the molecular mechanisms regulating their development, maturation, and activation are still poorly understood. GATA-3 is a T cell-specific transcription factor that is also expressed in iNKT cells. The critical role of GATA-3 in conventional alphabeta T cells has been well documented, but whether GATA-3 also re...
Purpose:Most studies characterizing antitumor properties of invariant natural killer T (iNKT) cells have used the agonist, a-galactosylceramide (a-GalCer). However, a-GalCer induces strong, long-lasting anergy of iNKT cells, which could be a major detriment for clinical therapy. A novel iNKT cell agonist, b-mannosylceramide (b-ManCer), induces strong antitumor immunity through a mechanism disti...
Following inoculation of Ag into the anterior chamber (a.c.), systemic tolerance develops that is mediated in part by Ag-specific efferent CD8(+) T regulatory (Tr) cells. This model of tolerance is called a.c.-associated immune deviation. The generation of the efferent CD8(+) Tr cell in a.c.-associated immune deviation is dependent on IL-10-producing, CD1d-restricted, invariant Valpha14(+) NKT ...
Mouse and human iNKT cell agonist β-mannosylceramide reveals a distinct mechanism of tumor immunity.
Type 1 or invariant NKT (iNKT) cell agonists, epitomized by α-galactosylceramide, protect against cancer largely by IFN-γ-dependent mechanisms. Here we describe what we believe to be a novel IFN-γ-independent mechanism induced by β-mannosylceramide, which also defines a potentially new class of iNKT cell agonist, with an unusual β-linked sugar. Like α-galactosylceramide, β-mannosylceramide dire...
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