نتایج جستجو برای: intrinsic pathway
تعداد نتایج: 405277 فیلتر نتایج به سال:
Despite improved diagnostic and therapeutic intervention, advanced prostate cancer (PC) remains incurable. The acquired resistance of PC cells to current treatment protocols has been traced to apoptosis resistance based on the upregulation of anti-apoptotic proteins of the Bcl-2 family. The use of BH3 mimetics, mimicking pro-apoptotic activator or sensitizer proteins of the intrinsic apoptotic ...
Transcriptional profiling is a prevalent and powerful approach for capturing the response of crop plants to environmental stresses, e.g., response of rice to drought. However, functionally interpreting the resulting genome-wide gene expression changes is severely hampered by the large gaps in our genomic knowledge about which genes work together in cellular pathways/processes in rice. Here, we ...
Living systems continuously interact with their environment, and many factors in the environment are not kind to the organisms. The entire biological history is a reflection of this incessant antagonism between the organism and its environment: the diversity of life forms is primarily the result of this dynamic conflict, which is perceived by the organisms or its cells as "stress." These stress...
T. J. GOODWIN, L. COATE-LI, R. M. LINNEHAN, AND T. G. HAMMOND Cellular Biotechnology Program, Flight Definition/Cell Biology, National Aeronautics and Space Administration, Johnson Space Center, Wyle Laboratories, Life Sciences-Systems and Services, and Flight Crew Operations, National Aeronautics and Space Administration, Johnson Space Center, Houston, Texas 77058; and Tulane Environmental Ast...
[This corrects the article DOI: 10.1371/journal.pone.0161486.].
Neurotransmitter-induced effects on motility of ileum from mouse and guinea pig: inhibition by plant extracts.
Populations of cells need to express proteins to survive the sudden appearance of stressors. However, these mechanisms may be taxing. Populations can introduce diversity, allowing individual cells to stochastically switch between fast-growing and stress-tolerant states. One way to achieve this is to use genetic networks coupled with noise to generate bimodal distributions with two distinct subp...
Multicellular organisms shape development and remove aberrant cells by programmed cell death ("apoptosis"). Because defective cell death (too little or too much) is implicated in various diseases (like cancer and autoimmunity), understanding how apoptosis is regulated is an important goal of molecular cell biologists. To this end, we propose a mathematical model of the intrinsic apoptotic pathw...
Proteolysis is a key regulatory process that promotes the (in)activation, translocation, and/or degradation of proteins. As such, there is considerable interest in methods to comprehensively characterize proteolytic pathways in biological systems. Here, we describe a robust and versatile proteomic platform that enables direct visualization of the topography and magnitude of proteolytic events o...
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