OBJECTIVE Interstitial cystitis is a condition with a poorly understood etiology and, consequently, various treatment options have been described in the literature, with a less than optimal outcome. The aim of this study was to examine the role of a combination of intravesical hydrocortisone and heparin, together with oral bladder sedatives and systemic triamcinolone, for the treatment of inter...

Intravesical bacille Calmette-Guérin (BCG) has been used by urologists for several years after its first reported use as a cancer therapy in the 1930s. Morales in 1976 described the usage of BCG as a once weekly intravesical instillation for six weeks; this is a treatment regimen that still exists today. Its success as a treatment depends on it being used appropriately. It is employed: (1) to t...

Bladder pain syndrome (BPS) causes decreased mental and physical quality of life. The diagnosis treatment BPS must be made effective; however, the was still not satisfactory for most patients. Two cases were presented to urology clinic treated with a combination hydrodistention intravesical hyaluronic acid (HA) periodically. After 3-8 hydrodistension instillation, patients showed symptom improv...

Intravesical instillation of BCG or anticancer agents after transurethral resection is currently considered a standard of therapy. However, this approach is basically empirical; none of the anticancer agents used in this setting was specifically formulated for intravesical therapy. Moreover, concern is raised by the kinetic features of water soluble drugs, because of poor transport across the m...

Intravesical instillation allows for direct exposure of the urothelium to a drug. However, therapeutic efficacy is often limited by rapid elimination drug from bladder. In this investigation, it hypothesized that morphology nanoparticulate delivery systems could significantly impact bioadhesion and bioelimination Bioadhesion kinetics evaluated ex vivo on rat bladder mucosa demonstrates particle...

BACKGROUND The clinical effect of intravesical instillation of chemotherapy immediately after transurethral resection of bladder tumours (TURBT) has recently been questioned, despite its recommendation in guidelines. Our aim was to compare TURBT alone with immediate post-TURBT intravesical passive diffusion (PD) of mitomycin and immediate pre-TURBT intravesical electromotive drug administration...

The anti-tumor effect of twice a week instillation of 30 mg mitomycin C combined with 200 mg cytosine arabinoside dissolved in 30 ml saline was studied in 37 bladder tumor patients. Endoscopic or histological disappearance of the tumor was observed in 19 cases, average instillation being 16.4 times. Small (less than 1 cm in diameter), low grade, low stage and villous-surfaced tumors were more s...

Intravesical instillation of bacille Calmette-Guérin (BCG) effectively treats transitional cell carcinoma of the bladder. Occasionally, BCG infection complicates such treatment. In some patients, infection appears early (within 3 months after instillation) and is characterized by generalized symptoms, with pneumonitis and hepatitis. Late-presentation disease occurs >1 year after the first BCG t...