With recent advancements in anaesthetic management where newer drugs and innovative treatment modalities are being introduced, the healthcare cost has increased it is prudent to reduce expenditure a developing country such as Sri Lanka without compromising on patient care. Reducing drug wastage, can impact hospitals pharmaceutical budget. The present study was conducted assess wastage of intrav...

Remimazolam, a novel, ultra-short-acting intravenous anesthetics, belongs to the benzodiazepine class of drugs and was approved for as general anesthetic. Its pharmacological action is similar that midazolam. However, differences in metabolic pathway pharmacokinetic profiles its metabolites contribute faster offset remimazolam than The context-sensitive half time (CSHT) short 6.8 ± 2.4 min. An ...

BACKGROUND A study was made to identify the most effective protocol for reducing the risk of osteonecrosis of the jaws (ONJ) following tooth extraction in patients subjected to treatment with antiresorptive or antiangiogenic drugs. MATERIAL AND METHODS A MEDLINE and SCOPUS search (January 2003 - March 2015) was made with the purpose of conducting a systematic literature review based on the Pr...

Epilepsy is a chronic disorder of the brain affecting around 50 million people in the world.Up to 30% of epileptic patients do not respond to available drugs and medical therapies. In thispaper, anticonvulsant screening of 10 synthesized new derivatives of 1, 4-dihydropyridine-3,5-dicarboxamides was performed.Anticonvulsant activity was evaluated by intravenous and intraperitoneal pentylenetetr...

A simple iterative process can be used to generate intravenous drug infusion profiles. It overcomes limitations in deriving compartmental pharmacokinetic models and has application to evaluation of new drugs and to clinical practice.

Introduction: Thrombopoietin receptor agonists are commonly second-line drugs in immune thrombocytopenia (ITP) pharmacotherapy children and prescribed for chronic ITP refractory to first-line therapy.
 Standard children: includes prescribing glucocorticoids or intravenous immunoglobulins.
 agonists: Currently Romiplostim Eltrombopag used the Russian Federation pediatrics. Their pharma...

Erythema multiforme (EM) is an uncommon acute mucocutaneous illness with target lesions primarily on the face and limbs. Slow-onset hypersensitivity reactions to infections (including herpes simplex virus mycoplasma pneumonia) medicines antibiotics, anticonvulsants, nonsteroidal anti-inflammatory drugs) cause EM. A 4-year-old male EM after taking metamizole, ampicillin, cloxacillin, unknown puf...

Sydenham’s chorea (SC) is common cause of acquired in childhood. SC occurs mainly children with untreated streptococcal infections. An effective list therapeutic options has been used to treat this disorder: antiepileptic drugs (valproic acid, carbamazepine etc.), haloperidol, chlorpromazine, amphetamines, steroids, plasma exchange and intravenous immunoglobulins (IVIG). We report a 12-year-old...

Since many drugs are cytochrome P450 (CYP)-3A4 substrates, it has become common practice to assess drug-drug interaction (DDI) potential with a CYP3A4 inhibitor (ketoconazole) or inducer (rifampicin) in early drug development. Such an evaluation is relevant to anticancer drugs with metabolism governed by CYP3A4. DDIs with rifampicin are complex, involving other physiological mechanisms that may...