backround: we aimed to evaluate analgesic efficacy, opioid-sparing, and opioid-related adverse effects of intravenous paracetamol and intravenous dexketoprofen trometamol in combination with iv morphine after total abdominal hysterectomy. materials and methods: sixty american society of anesthesiologist physical status classification i-ii patients scheduled for total abdominal hysterectomy were...

AIM Opioids are increasingly used to control postoperative pain via intravenous patient-controlled analgesia, with several advantages. The present study evaluated the effects of intravenous patient-controlled analgesia with different doses of fentanyl on postoperative pain and on the quality of physical/emotional recovery from surgery and anesthesia. METHODS We retrospectively reviewed data f...

BACKGROUND Postoperative pain mostly results from sensitization of afferent fibers at injury sites driving central sensitization. Recently, peripheral processes have gained attention as mechanisms of hyperalgesia, and prostaglandins are among highly sensitizing agents. To date, perioperative administration of a single local dose of nonsteroidal antiinflammatory drugs has shown inconclusive effi...

BACKGROUND Intravenous acetaminophen injection (paracetamol) is marketed in Europe for the management of acute pain. A repeated-dose, randomized, double-blind, placebo-controlled, three-parallel group study was performed to evaluate the analgesic efficacy and safety of intravenous acetaminophen as compared with its prodrug (propacetamol) and placebo. Propacetamol has been available in many Euro...

BACKGROUND Clonidine has been added to local anesthetic regimens for various peripheral nerve blocks, resulting in prolonged anesthesia and analgesia. The authors postulated that using clonidine as a component of intravenous regional anesthesia (IVRA) would enhance postoperative analgesia. METHODS Forty-five patients undergoing ambulatory hand surgery received IVRA with lidocaine, 0.5%, and w...

conclusions the addition of ketamine to intravenous fentanyl plus acetaminophen pca had not extra effects in relieving post abdominal surgery pain. results there were no significant demographic differences between two groups. pain scores (at rest, while moving and coughing) during the first 48 hours were not significantly different between two groups (p values = 0.361, 0.367 and 0.204, respecti...

BACKGROUND Offset analgesia, in which a disproportionally large amount of analgesia becomes apparent upon a slight decrease in noxious heat stimulation, has not been described previously in patients with chronic pain. METHODS Offset analgesia responses in 10 patients with neuropathic pain (in both legs) were compared with 10 matched healthy controls and volunteers from a convenience sample (n...