Infection of the amniotic cavity remains a major cause of preterm birth, stillbirth, fetal injury and early onset, fulminant infections in newborns. Currently, there are no effective therapies to prevent in utero infection and consequent co-morbidities. This is in part due to the lack of feasible and appropriate animal models to understand mechanisms that lead to in utero infections. Use of mou...

No single diagnostic test for cytomegalovirus (CMV) infection is currently available for pregnant women at all stages of gestation. Improved accuracy in estimating the timing of primary infections can be used to identify women at higher risk of giving birth to congenitally infected infants. A diagnostic algorithm utilizing immunoglobulin G (IgG), IgM, and IgG avidity was used to prospectively s...

Background: To evaluate the effectiveness of intrauterine injection of recombinant human chorionic gonadotropin (rhCG) before embryo transfer (ET). Materials and Methods: In this randomized placebocontrolled clinical trial, a total number of 182 infertile patients undergoing their first in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI) were randomly assigned to receive 250 μg i...

There is evidence that fetal antigenic stimulation and intrauterine infection is much more frequent in developing rural populations than in industrialized societies. A similar contrast is observed for postnatal intestinal infection that is significantly greater in the less developed areas. The differences are explained by the divergence in environmental sanitation and personal hygiene. Intestin...

Despite being the commonest inherited disease of bone, osteogenesis imperfecta (OI) is a rare cause of fractures in daily clinical practice. Its prevalence in the general population is 1 to 5 per 100 000. The clinical spectrum ranges from mild forms with relatively few fractures and normal mobility to the lethal form, with multiple intrauterine fractures and death in perinatal period. The diagn...

BACKGROUND Atypical presentation of tuberculosis (TB) during pregnancy may cause diagnostic delay and adversely influence pregnancy outcome. OBJECTIVES To examine the incidence and clinical and epidemiological features of TB during pregnancy and investigate infection control measures at delivery and during the postpartum period. METHODS We retrospectively evaluated all reported cases of TB ...

In mammals, the intrauterine condition has an important role in the development of fetal physiological systems in later life. Suboptimal maternal environment can alter the regulatory pathways that determine the normal development of the fetus in utero, which in post-natal life may render the individual more susceptible to cardiovascular or metabolic adult-life diseases. Changes in the intrauter...

background: intrauterine insemination (iui) is one of the most appropriate and cost-effective methods in infertility treatment. objective: we aimed to investigate effect of vaginal misoprostol on pregnancy rate after iui. materials and methods: two hundred and ten infertile women who were referred to infertility clinic of alzahra hospital by an indication of iui during 2012-2013 were randomly a...

oligohydramnios is frequently used to identify at risk fetuses. the purpose of this study was to assess adverse perinatal outcomes in oligohydramnios. subjects comprised pregnant women diagnosed either with (590) or without (597) oligohydramnios who delivered after hospital admittance from 2000 to 2010 . data, including the resuscitation of newborn, apgar score at 5 min, nicu admission, death i...