OBJECTIVE To test the validity of the fetal origins hypothesis and the classic twin method. DESIGN Follow up study of pairs of same sex twins in which both twins survived to age 6. SETTING Denmark. SUBJECTS 8495 twin individuals born 1870-1900, followed through to 31 December 1991. MAIN OUTCOME MEASURES Mortality calculated on a cohort basis. RESULTS Mortality among twins and the gene...

the interpretation of supernumerary chromosome is important for genetic counseling and prognosis. here, we used snp array and conventional karyotyping method to identify a denovo marker chromosome originated from chromosome 22 and 11 in a newborn transferred to the neonatal intensive care unit of shahid sadoughi hospital in 2015.  clinical abnormalities identified in the newborn were dysmorphic...

We report an infant with pre- and postnatal microcephaly and growth retardation, a distinctive face, and developmental delay. The initial diagnosis was of Seckel syndrome. He became pancytopenic at 16 months and died soon after. His bone marrow was of normal cellularity but had a small lymphocyte infiltration. Increased spontaneous chromosome breakage was seen in blood and fibroblasts. Mitomyci...

Submit Manuscript | http://medcraveonline.com Abbreviations: CMV: Cytomegalovirus; HIV: Human Immunodeficiency Virus; VDRL: Venereal Disease Research Laboratories; IUGR: Intrauterine Growth Retardation; PCR: Polymerase Chain Reaction; NICU: Neonatal Intensive Care Unit; IVIG: Intravenous Immunoglobulin; PDA: Patent Ductusarteriosus; LV: Left Ventricle; LVEDD: Left Ventricular End Diastolic Dime...

The 10q26 subtelomeric microdeletion syndrome is a rare and clinically heterogeneous disorder. precise relationships between the causative genes phenotype are unclear. We report two new cases of 860 kb deletion 10q26.2 identified by array CGH in fetus with intrauterine growth retardation his mother. deleted region encompassed only four coding genes, DOCK1, INSYN2, NPS FOX12. proband had dysmorp...