Many anesthetic techniques are currently used for extracorporeal shock wave lithotripsy (ESWL). This randomized, prospective, double-blind study was designed to examine postoperative recovery with two anesthetic techniques for unilateral ESWL; i.e., intrathecal sufentanil versus intrathecal5% lidocaine. The incidence of adverse effects was also assessed. Twenty-two ASA physical status I-III pat...

BACKGROUND Intrathecal IgM synthesis is reported to be associated with a worse prognosis in adults with multiple sclerosis (MS). OBJECTIVE To study the predictive value of intrathecal IgM synthesis for the clinical course of pediatric MS. METHODS Seventy children with onset of MS before the age of 16 years and followed for a median period of 10.4 years (range: 0.4-22.8 years) were studied. ...

BACKGROUND As the incidence of meningeal carcinomatosis (MC) in non-small cell lung cancer (NSCLC) patients has been increasing, MC has recently become an important clinical problem in the management of NSCLC. However, development of new treatments is lacking and a standard treatment guideline is not yet available. Research on salvage intrathecal chemotherapy after failure of first-line treatme...

ObjectiveTo assess the success rate, procedure time, and adverse events of intrathecal administration nusinersen via paramedian approach in adolescents adults with spinal muscular atrophy (SMA) associated scoliosis.MethodsSeven patients genetically confirmed SMA (age, 12–40 years) were included. Intrathecal was performed using fluoroscopy after determination largest interlaminal foramen among L...

FULLY implantable devices or drug–device combinations, such as intrathecal drug delivery (DD) systems and spinal cord stimulation (SCS) systems, increasingly are used for the treatment of chronic intractable pain. Another approved indication for intrathecal DD systems is the administration of intrathecal baclofen (ITB) to treat medically intractable spasticity of spinal or cerebral origin. Alth...

BACKGROUND Studies have reported that prophylactic continuous infusion of phenylephrine during spinal anesthesia for cesarean section can decrease the spread of local anesthetics. We investigated the ED50 of intrathecal hyperbaric ropivacaine in parturient women undergoing cesarean section under prophylactic infusion of phenylephrine. METHODS Sixty parturient women were allocated into 2 group...

BACKGROUND The degree to which intrathecally administered morphine can alleviate hypersensitivity in animals after peripheral nerve injury is controversial, and the mechanisms by which morphine works in these circumstances are uncertain. In normal animals, morphine induces adenosine release, and in vitro data suggest that this link is disrupted after peripheral nerve injury. Therefore, using a ...

Introduction: The use of epidural analgesia in patients with implanted intrathecal delivery devices is somewhat controversial. Major concerns include the risk of damaging the intrathecal catheter, the risk of infection, and the potential for interaction between the epidurally-administered and the intrathecally-delivered medication. In children with cerebral palsy, intrathecal administration of ...

ber 1999) that demonstrate little difference in dermatomal spread in CSF of fentanyl compared with morphine after intrathecal injection. Thus, the extrapolation from pigs to humans and from models of CSF and tissue kinetics to clinical effects is far from certain. In summary, the article by Ummenhofer et al. is a seminal work in intrathecal pharmacokinetics. It directly incorporates location in...

At the present time, anti-inflammatory, immunomodulatory, or immunosuppressive treatments of multiple sclerosis (MS) are mainly effective in the early phases of the disease but are of less advantage in progressive phases. Current therapeutic strategies of both primary and secondary progressive MS are rare. One alternative may be intrathecal application of triamcinolone acetonide (TCA). Number o...