The estrogenic activity of the chemical UV-filters, 4-methylbenzylidene camphor (4-MBC) and octyl methoxy cinnamate (OMC) was investigated in an vivo rainbow trout ( Oncorhynchus mykiss ) assay. Plasma vitellogenin concentrations were quantified by means Enzyme Linked Immuno Sorbent Assay (ELISA) juvenile before after intraperitoneal injection test compounds. Injection 4-MBC on day 0, 3, 6 10 e...

AIM As reported previously, porcine skin gelatin exerted direct anti-tumor effect in vitro and induced anti-tumor peritoneal macrophages in vitro. The present study investigated whether or not the gelatin exerted anti-tumor effect in vivo. METHODS In vitro anti-tumor activities of peritoneal macrophages and the gelatin were evaluated with tritium thymidine uptake by target tumor cells. In viv...

PURPOSE To investigate the effect of ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) on retinal ganglion cell (RGC) survival and nitric oxide synthase (NOS) expression in the retina during the early phase of optic nerve (ON) injury, and to examine whether intraperitoneal application of the NOS scavenger nitro-l-arginine (l-NA) could protect the injured RGCs. ME...

UNLABELLED Small-animal PET provides the opportunity to image brain activation during behavioral tasks in animal models of human conditions. The present studies aimed to simplify behavioral imaging procedures without a loss of quantitation by using an intraperitoneal route of administration (no cannulation, no anesthesia) and using a standardized uptake value (SUV) to reduce scan duration. ME...

After Blum's discovery of the production of glycosuria by the subcutaneous injection of adrenal extract, Herter has the merit of having found that injection of adrenalin into the peritoneal cavity also produces glycosuria; this is an undeniable fact. Concerning Herter's claim that intraperitoneal injection gives a higher degree of glycosuria than subcutaneous or intravenous injection, we offer ...

Stem cell transplantation showed promising results in IBD management. However, the therapeutic impacts of cell delivery route that is critical for clinical translation are currently poorly understood. Here, three different MSCs delivery routes: intraperitoneal (IP), intravenous (IV), and anal injection (AI) were compared on DSS-induced colitic mice model. The overall therapeutic factors, MSCs m...

Background: Acute pancreatitis (AP) is a typical destructive inflammation of the pancreas. The direct effect L. wallichii on AP remains unknown.Methods: animal model was constructed by intraperitoneal injection caerulein in male Sprague–Dawley rats. extracts were used to treat rats with AP. Then, tissue injury evaluated hematoxylin and eosin staining. Serum indicators, including amylase, lipase...

OBJECTIVES This report reviews the carcinogenicity of multi-walled carbon nanotubes (MWCNTs) in experimental animals, concentrating on MWNT-7, a straight fibrous MWCNT. METHODS MWCNTs were administered to mice and rats by intraperitoneal injection, intrascrotal injection, subcutaneous injection, intratracheal instillation and inhalation. RESULTS Intraperitoneal injection of MWNT-7 induced p...

The toxic and carcinogenic actions of four methylnitrosamine or -amide compounds, given as a single intraperitoneal injection to newborn and adult inbred Swiss mice, were examined. Toxicity was approximately directly proportional to the stability of the three compounds capable of methylating macromolecules in vitro. Methylnitrosourea induced a high incidence of thymic lymphomas in adults and ne...