The intraocular pressure lowering effect in 30 patients with raised intraocular pressure and open angles following a single application in a randomised double-masked fashion of four concentrations of D-timolol (0.25%, 0.5%, 1.0%, and 2.0%), 0.25% L-timolol, and placebo are presented. The percentage reduction in intraocular pressure after four hours following single-drop instillation range from ...

Treatment of glaucoma continues to be directed at lowering intraocular pressure to decrease the likelihood of disease progression. In the future intraocular pressure reduction might be augmented by other therapeutic approaches. Interest has been increasing in preventing progression of glaucomatous optic neuropathy using approaches based on the premise that glaucoma is a neurodegenerative diseas...

When Policy Topic is covered Canaloplasty may be considered medically necessary as a method to reduce intraocular pressure in patients with chronic primary open-angle glaucoma under the following conditions:  Medical therapy has failed to adequately control intraocular pressure, AND  The patient is not a candidate for any other intraocular pressure lowering procedure (e.g. trabeculectomy or g...

Background: Succinylcholine remain unsurpassed in providing ideal intubating conditions in the shortest time among all available neuromuscular blocking agents hence is advocated as the drug of choice for rapid sequence endotracheal intubation. Aim: Study compared the effects of succinylcholine and rocuronium bromide on intraocular pressure. Materials and methods: Study was done in 30 samples of...

PURPOSE The purpose of this study was to evaluate the effects of intraocular pressure on the permeability of human and rabbit sclera to water, dexamethasone, and carboxyfluorescein. METHODS Scleral sections excised from moist-chamber-stored human globes or eyes obtained from euthanatized New Zealand White rabbits were mounted in a perfusion chamber that can create a transscleral pressure that...

Changes in both intraocular pressure and total outflow facility were determined after short- and long-term infusion and topical application of prostaglandin E1 and E2. The intraocular pressure with both routes of administration increased within 15 minutes by 10 to 15 mm. Hg; long-term infusion caused the intraocular pressure to be elevated for a longer time, although a fall in intraocualr press...

An equation has been derived under simplified assumptions showing how the steady-state value of intraocular pressure depends on rate of secretion of aqueous, episcleral venous pressure, outflow facility at the chamber angle, colloid-osmotic pressure of the blood, systemic arterial blood pressure, pressure distribution over the vascular tree of the eye, and filtration properties of the vasculatu...

The aim of this study was to investigate the association between postprandial glucose and intraocular pressure in a relatively healthy population. We examined 1,439 adults getting a health check-up in a health promotion center at Tri-Service General Hospital (TSGH) in Taiwan between 2012 and 2013. All participants underwent examinations to measure metabolic variables and intraocular pressure. M...

In an attempt to determine the presence or absence of correlation between the intraocular pressure-increasing and pupil-dilating effects of corticosteroids, the effect of topically applied dexamethasone and various autonomic agents has been studied in 12 hospitalised, healthy, young adult volunteers. Dexamethasone caused an average increase of intraocular pressure of 8-8 mmHg and of pupillary d...

Axonal transport in primate optic nerve axons was studied by autoradiography, scintillation counting, and electron microscopy under conditions of short-term intraocular pressure elevation. With elevation of intraocular pressure to 30 mm. Hg below mean arterial blood pressure, blockage of transport was detected within 2 hours by autoradiography and within 1 hour by electron microscopy. The earli...