OBJECTIVE To examine use of the paramedian forehead flap for intranasal lining. METHODS The medical records and photographs were reviewed for patients who underwent a nasal reconstruction involving a paramedian forehead flap used for internal lining. RESULTS Three patients underwent this procedure. In all patients, the flap provided excellent intranasal lining. External incisions were accep...

although response to intranasal steroid therapy has been reported in pa¬tients with allergic rhinitis, efficacy of some nasal steroids is noteworthy. this study was undertaken to evaluate the efficacy of a two-week course of fluticasone (flixonase) nasal spray vs. beclomethasone (beconase) nasal spray in patients with symptoms of allergic rhinitis referred to our clinic. this study reviewed six...

BACKGROUND Correct use of intranasal corticosteroid (INCS) and compliance with treatment is very important for the treatment of allergic rhinitis (AR). An animated cartoon-aided teaching method for INCS administration was created to decrease the workload of health care professionals. The aim of this study was to compare the performance of children with AR in using INCS between a group who were ...

The goal of brain drug targeting technology is the delivery therapeutics across blood barrier (BBB), including human BBB. Nose to has received a great deal attention as non- invasive, convenient and reliable system. For systemic targetedadministration drug. various deliveries through some transport pathways, Factor influencing nasal absorption, formulation strategies nose brain, colloidal carri...

Oxytocin has been implicated in a variety of prosocial processes but most of this work has used laboratory tasks (such as the ultimatum game or the dictator game) to evaluate oxytocin's prosocial effects. In a double blind randomized trial we examined the influence of intranasal administration of oxytocin on real, high-cost donating money to a charity without any expectation for reciprocation. ...

BACKGROUND AND AIMS Preprocedural preparation of children scheduled for magnetic resonance imaging (MRI) is challenging. This prospective, randomized trial compared intranasal midazolam with intranasal dexmedetomidine as premedication for children scheduled for brain MRI. MATERIAL AND METHODS In total, 60 children, aged 1-8 years, scheduled for elective brain MRI, were randomly assigned to th...

Previous studies have shown that intranasally administered insulin exerts an inhibitory influence on the basal hypothalamic-pituitary-adrenal (HPA) axis activity. To date, however, it remains unclear as to whether intranasal insulin does furthermore affect HPA axis responsiveness in situations of stress. Here, we tested whether intranasally administered insulin attenuates the HPA axis response ...

Recent evidence reveals that aberrant brain insulin signaling plays an important role in the pathology of Alzheimer's disease (AD). Intranasal insulin administration has been reported to improve memory and attention in healthy participants and in AD patients. However, the underlying molecular mechanisms are poorly understood. Here, we treated intracerebroventricular streptozotocin-injected (ICV...

Studies in rodents suggest that insulin controls hepatic glucose metabolism through brain-liver crosstalk, but human studies using intranasal insulin to mimic central insulin delivery have provided conflicting results. In this randomized controlled crossover trial, we investigated the effects of intranasal insulin on hepatic insulin sensitivity (HIS) and energy metabolism in 10 patients with ty...

Socio-emotional deficits and impulsive/aggressive outbursts are prevalent symptoms of many neuropsychiatric disorders, and intranasal administration of oxytocin (OXT) is emerging as a putative novel therapeutic approach to curb these problems. Recently, we demonstrated potent anti-aggressive and pro-social effects of intracerebroventricular (icv) OXT administration in male rats. The present stu...