Oxytocin antagonist (OTA), TT-235, was developed by our group and shown to inhibit either spontaneous or oxytocin-induced uterine contractions in primates. The purpose of the present study was to confirm the duration of TT-235 to block oxytocin-induced uterine contractions in estrous rats. In Experiment 1, the time-response of the three OTAs on uterine contractility was examined. The rats were ...

The effect of exogenous oxytocin on milk yield is studied in a series of experiments on the dairy ewe. Experiments I and II. A non-galactokinetic dose (o.oi and 0.5 IU/hr) injected into the carotid artery did not change milk yield. The results do not seem to confirm central oxytocin action on the lactogenic hormonal complex of the hypophysis. Experiments III, IV, V. IV injection of oxytocin (0....

Pregnancy and child birth involves significant health risk even for women with no pre-existing health problems. Third stage of labour is the time from delivery of the baby until delivery of the placenta and is the most crucial stage of labour. Post partum hemorrhage complicates approximately 4% of vaginal deliveries and estimates are that it causes significant morbidity and 25% of all the child...

I n the report by Yin et al, 1 the statement that “many clinicians may misinterpret these directions (in paliperidone palmitate product monograph) to mean that these intramuscular sites (deltoid or gluteal) are interchangeable, and thus therapeutically equivalent” is, in our opinion, not correct. We are writing to clarify some statements from the Yin et al article concerning the deltoid versus ...

The pharmacokinetics of ceftriaxone were investigated in six healthy adults. One-gram doses were administered either intramuscularly or intravenously in a crossover design study. Mean peak ceftriaxone concentrations in plasma of 79.2 and 123.2 micrograms/ml were achieved with intramuscular injection and intravenous infusion, respectively, with plasma half-lives of 5.4 and 5.8 h. The urinary rec...

The rapid corticotropin test with synthetic corticotropin ( 1-24 peptide) was studied. A single intravenous injection of the corticotropin was performed in 26 human subjects. The increment of plasma 11-0HCS concentration by the administration was less than that of NH-corticotropin dripping infusion or synthetic corticotropin intramuscular injection. Intramuscular rapid corticotropin test was co...

The objective of this study was to compare the course of parturitions induced with sole oxytocin with those induced with the combination of intracervical prostaglandin E2 jelly and oxytocin. For this purpose 13 mares in advanced pregnancy were allocated to the groups pretreated with either intracervical PGE2 (experimental group) or saline (control group) two hours before intravenous oxytocin (5...

BACKGROUND AND PURPOSE The effect of Oxytocin on energy metabolism is still question. The aim of the present study was to investigate the effect of exogenous oxytocin injection in different dose and timetable on blood glucose level in rat. EXPERIMENTAL APPROACH In this study 16 adult female rats were divided into 2 groups (Treatment 1(T1) and Treatment 2(T2)). T1 with 8 adult female rats rece...