Several 3,4-disubstituted indole building blocks were synthesized, containing a one-carbon functional group at C-4 and a three-carbon chain bearing at least one functional group. A C-4 functionalized indole derivative was prepared by application of the Leimgruber-Batcho reaction. Several three-carbon chains were subsequently installed at the indole C-3 position. In the first strategy employed, ...

Organocatalysts activate substrates through mild noncovalent and covalent interactions, their cooperative actions at multiple catalytic sites are essential even in intrinsically rapid organic reactions such as intramolecular cyclizations. The enzyme-like system is effective for recognizing specific molecular conformations of substrates, which continually change under reaction conditions, multip...

in the present work, an extensive theoretical calculation study on histidine-histidine dipeptide in gas phase is done by using dft method with gaussian 98 program. through investigations on the molecular geometries of this molecule it is found that there is six rings in the molecules not two rings. the presence of four intramolecular hydrogen bonds is responsible for the formation of additional...

Hydrogenated [60]fullerenes, prepared from [60]fullerene and sodium borohydride, react with alkylidenecyanoacetates [RCH=CCN(CO2Et): R 1⁄4 C6H5 (2a), 4-CH3O–C6H4 (2b), 4-NO2–C6H4 (2c), H (2d)] and alkylidenemalononitriles [RCH=C(CN)2 : R 1⁄4 C6H5 (2e), 4-CH3O–C6H4 (2f), 4-NO2–C6H4 (2g), 4-(CH3)2N–C6H4 (2h)] under basic conditions to afford cyclopentenylfullerenes 3. No multi-cycloaddition produ...

The NHC-catalyzed reactions of ortho electron-deficient vinyl substituted arylaldehydes with nitrosoarenes were studied. The reactions produced multifunctional 2,3-benzoxazin-4-ones in good to excellent yields via a cascade aza-benzoin reaction between aldehyde and nitroso groups followed by an intramolecular oxo-Michael addition. The resulting 1-acetate substituted 2,3-benzoxazinones were tran...

An enantioselective synthesis of the quinolizidine alkaloid (K)-lasubine II 1 is reported. Two different pathways to the key intermediate 2 are described. The first case involving a sequence of ring rearrangement metathesis (RRM), simple functional group interconversion operations, followed by a stereoselective cross metathesis (CM) and in the second case a domino ring opening-/ring closing-/ c...

The catalytic enantioselective synthesis of a range of cis-pyrrolizine carboxylate derivatives with outstanding stereocontrol (14 examples, >95 : 5 dr, >98 : 2 er) through an isothiourea-catalyzed intramolecular Michael addition-lactonisation and ring-opening approach from the corresponding enone acid is reported. An optimised and straightforward three-step synthetic route to the enone acid sta...