Phorbol 12-myristate 13-acetate (PMA) was used to examine the role of insulin receptor phosphorylation in the regulation of insulin receptor internalization in vascular endothelial cells. Association of 125I-insulin in rat capillary and bovine aortic endothelial cells preincubated with PMA was increased by 80 and 64% over control, respectively. The increase was due to enhanced 125I-insulin inte...

Serotonin (5-HT), a major neurotransmitter, has a large number of G protein-coupled receptors in mammals. On activation by exposure to their ligand, 5-HT(2) receptor subtypes increase IP(3) levels and undergo desensitization and internalization. To visualize the receptor in cells during these processes, we have constructed a 5-HT(2A)-enhanced GFP (SR2-GFP) fusion receptor. We show that this fus...

Receptor ligands, identified as antagonists, based on the absence of stimulation of signaling, can rarely stimulate receptor internalization. d-Tyr-Gly-[(Nle(28,31),d-Trp(30))CCK-26-32]-2-phenylethyl ester (d-Trp-OPE) is such a ligand that binds to the cholecystokinin (CCK) receptor and stimulates internalization. Here, the molecular basis of this trafficking event is explored, with the assumpt...

This study examined the relationships of sociocultural body ideal internalization, difficulties in emotion regulation, and their interaction with image concerns a group 423 adolescent boys. Participants were aged from 12 to 17 years old completed multiple self-reported questionnaires. Regression analyses latent moderation structural equations performed. Both variables positively correlated diss...

The present study investigated the association between body talk on social networking sites (SNS) and dissatisfaction as well mediating effects of appearance ideals internalization comparison in this relationship. Participants were 476 Chinese college students who completed questionnaires regarding SNS talk, thin-ideal internalization, muscular-ideal general attractiveness comparison, dissatisf...

Using an ultrathin film substrate, the first internalization of MoS2 nanosheets through mechanotransduction is demonstrated. The usual method dispersing nanomaterials in media limits interac...