Intermittent transdermal therapy of nitroglycerin (NTG) has been recommended for the prevention of nitrate tolerance, but a rebound phenomenon has been reported to occur following removal of the NTG tape. The present study investigated the effects of intermittent NTG therapy on vasodilatory response and the intracellular production of cyclic GMP (cGMP). The study group comprised 12 healthy adul...

The purpose of this study was to compare chemoresponses following two different intermittent hypoxia (IH) protocols in humans. Ten men underwent two 7-day courses of poikilocapnic IH. The long-duration IH (LDIH) protocol consisted of daily 60-min exposures to normobaric 12% O(2). The short-duration IH (SDIH) protocol comprised twelve 5-min bouts of 12% O(2), separated by 5-min bouts of room air...

Editor’s note: Each month, Case Challenge features a discussion of an unusual diagnosis. A description and images are presented, followed by the diagnosis and an explanation of how the diagnosis was determined. Your comments are welcome via email at [email protected]. To submit a case, visit: www.PediatricSuperSite.com/Submit. A 16-Year-Old Girl with Chronic Intermittent Abdominal Pain

INTRODUCTION THIS PAPER is offered as a preliminary survey of mainstream writing about the pathology of fever in the sixteenth century. It is selective in the writers discussed, and confined to three topics: the definition of fever and febrile heat, the explanation of intermittent fevers, and the role of putrefaction.' The paper is partly concerned with the relation between tradition and innova...