Corticosteroids are standard treatment for patients with multiple sclerosis experiencing acute relapse. Because dyspeptic pain is a common side effect of this intervention, patients can be given a histamine receptor-2 antagonist, proton pump inhibitor or antacid to prevent or ameliorate this disturbance. Additionally, patients with multiple sclerosis may be taking these medications independent ...

a unique interferon-b signaling axis mediated via the receptor IFNAR1. Nat. Immunol. 14, 901–907. 8. Brierley, M. M., Marchington, K. L., Jurisica, I., Fish, E. N. (2006) Identification of GASdependent interferon-sensitive target genes whose transcription is STAT2-dependent but ISGF3-independent. FEBS J. 273, 1569–1581. 9. Krakauer, M., Sorensen, P., Khademi, M., Olsson, T., Sellebjerg, F. (200...

BACKGROUND Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the Central Nervous System that is immunologically mediated in genetically susceptible individuals. IL-21, a cytokine produced by TCD4(+) cells, particularly by Th-17 cells, is believed to play an important role in the MS pathogenesis. OBJECTIVE This study was performed to investigate the impact of genetic p...

1Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-University Munich, Munich, Germany. 2Institute of Molecular Immunology, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany. 3Institute for Multiple Sclerosis Research and Department of Neuroimmunology, Gemeinnützige Hertie-Stiftung, and University Medical Center Göttingen, Göttingen, Germany. 4...

Chronic immune activation in systemic sclerosis is supported by the production of a plethora cytokines with proven regulatory activities responses. This study aimed to explore PBMCs’ cytokine profiles SSc patients versus controls, as well investigate balance between pro- and anti-inflammatory association disease duration. PBMCs were isolated from 18 17 controls further subjected vitro stimulati...

Severe injury can initiate an exaggerated systemic inflammatory response and multiple organ failure (MOF) if a subsequent immune stimulus, "second hit", occurs. Using a mouse thermal injury model, we tested whether changes in innate immune cell reactivity following injury can contribute to the development of heightened inflammation and MOF. Using high-purity Escherichia coli lipopolysaccharide ...

Intracellular signals emanating from cytokine and antigen receptors are integrated during the process of intrathymic development. Still, the relative contributions of cytokine receptor signaling to pre-T cell receptor (TCR) and TCR-mediated differentiation remain undefined. Interleukin (IL)-7 interactions with its cognate receptor complex (IL-7Ralpha coupled to the common cytokine receptor gamm...

The purpose of this scientometric study is to analyze the multiple sclerosis research in Science Citation Index-Expanded from 1992 to 2019 in order to determine the top features, trends, and topics. Articles related to multiple sclerosis in the section of title, abstract, keywords, and KeyWords Plus were retrieved from the Science Citation Index-Expanded and analyzed based on various indicators...