نتایج جستجو برای: interleukin 23

تعداد نتایج: 280903  

Journal: :Journal of virology 2013
Jennifer A Manuzak Stephanie M Dillon Eric J Lee Zachary M Dong Daniel K Hecht Cara C Wilson

The level of microbial translocation from the intestine is increased in HIV-1 infection. Proinflammatory cytokine production by peripheral antigen-presenting cells in response to translocated microbes or microbial products may contribute to systemic immune activation, a hallmark of HIV-1 infection. We investigated the cytokine responses of peripheral blood myeloid dendritic cells (mDCs) and mon...

Journal: :Journal of pediatric gastroenterology and nutrition 2013
Mary E Sherlock Thomas Walters Merit M Tabbers Karen Frost Mary Zachos Aleixo Muise Elena Pope Anne M Griffiths

BACKGROUND Infliximab (IFX), an established therapy for pediatric Crohn disease (CD), is also efficacious in treating psoriasis, a skin disorder, in which tumor necrosis factor-α is implicated pathogenically. Paradoxically, there have been numerous reports of new-onset psoriasis following tumor necrosis factor-α antagonist therapy in adult patients with inflammatory bowel disease, but pediatric...

Journal: :Brain : a journal of neurology 2007
Yonghai Li Niansheng Chu Aihua Hu Bruno Gran Abdolmohamad Rostami Guang-Xian Zhang

IL-12 has long been considered important in the pathogenesis of multiple sclerosis. However, evidence from recent studies strongly supports the critical role of IL-12-related proinflammatory cytokine IL-23, but not IL-12, in the development of experimental autoimmune encephalomyelitis (EAE), an animal model of this disease. The role of IL-23 in the CNS immunity of multiple sclerosis patients ha...

2014
Samadhi Aparicio-Siegmund Jens M. Moll Juliane Lokau Melanie Grusdat Jutta Schröder Svenja Plöhn Stefan Rose-John Joachim Grötzinger Philipp A. Lang Jürgen Scheller Christoph Garbers Muriel Moser

The Interleukin (IL)-12 family contains several heterodimeric composite cytokines which share subunits among each other. IL-12 consists of the subunits p40 (shared with IL-23) and p35. p35 is shared with the composite cytokine IL-35 which comprises of the p35/EBI3 heterodimer (EBI3 shared with IL-27). IL-35 signals via homo- or heterodimers of IL-12Rβ2, gp130 and WSX-1, which are shared with IL...

Journal: :The Journal of Experimental Medicine 2005
Kyle I. Happel Patricia J. Dubin Mingquan Zheng Nico Ghilardi Christie Lockhart Lee J. Quinton Anthony R. Odden Judd E. Shellito Gregory J. Bagby Steve Nelson Jay K. Kolls

Interleukin (IL)-23 is a heterodimeric cytokine that shares the identical p40 subunit as IL-12 but exhibits a unique p19 subunit similar to IL-12 p35. IL-12/23 p40, interferon gamma (IFN-gamma), and IL-17 are critical for host defense against Klebsiella pneumoniae. In vitro, K. pneumoniae-pulsed dendritic cell culture supernatants elicit T cell IL-17 production in a IL-23-dependent manner. Howe...

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