نتایج جستجو برای: interleukin 17a

تعداد نتایج: 98851  

2017
Marika Orlov Victoria Dmyterko Mark M Wurfel Carmen Mikacenic

BACKGROUND CD4+ T-helper 17 (Th17) cells and Interleukin (IL)-17A play an important role in clearing pathogens in mouse models of pneumonia. We hypothesized that numbers of Th17 cells and levels of IL-17A are associated with risk for nosocomial pneumonia in humans. METHODS We collected bronchoalveolar lavage (BAL) fluid from mechanically ventilated (n = 25) patients undergoing quantitative ba...

Journal: :Infection and immunity 2010
Louise Henningsson Pernilla Jirholt Catharina Lindholm Tove Eneljung Elin Silverpil Yoichiro Iwakura Anders Linden Inger Gjertsson

Staphylococcus aureus is one of the dominant pathogens that induce septic arthritis in immunocompromised hosts, e.g., patients suffering from rheumatoid arthritis treated with immunosuppressive drugs. S. aureus-induced arthritis leads to severe joint destruction and high mortality despite antibiotic treatment. Recently, interleukin-17A (IL-17A) has been discovered to be an important mediator of...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2014
Susanne Karbach Andrew L Croxford Matthias Oelze Rebecca Schüler Daniel Minwegen Joanna Wegner Lija Koukes Nir Yogev Alexei Nikolaev Sonja Reißig Alexander Ullmann Maike Knorr Maximilian Waldner Markus F Neurath Huige Li Zhixiong Wu Christoph Brochhausen Jürgen Scheller Stefan Rose-John Carolin Piotrowski Ingo Bechmann Markus Radsak Philipp Wild Andreas Daiber Esther von Stebut Philip Wenzel Ari Waisman Thomas Münzel

OBJECTIVE Interleukin (IL)-17A is regarded as an important cytokine to drive psoriasis, an inflammatory skin disease marked by increased cardiovascular mortality. We aimed to test the hypothesis that overproduction of IL-17A in the skin leading to dermal inflammation may systemically cause vascular dysfunction in psoriasis-like skin disease. APPROACH AND RESULTS Conditional overexpression of ...

2017
Fabien Lavocat Ndiémé Ndongo-Thiam Pierre Miossec

The production and function of cytokines are highly regulated. One mechanism is the balance between pro- and anti-inflammatory cytokines. As interleukin (IL)-17A and IL-25 share the IL-17RA receptor chain, we hypothesize that IL-25 acts as an IL-17A receptor antagonist and limits its pro-inflammatory effects. The production and expression kinetics of IL-25 and its receptor chains IL-17RA and RB...

2017
Gordana VIJATOV-DJURIC Aleksandra DORONJSKI Igor MITIC Snezana BRKIC Nenad BARISIC

©2017 Turkish League Against Rheumatism. All rights reserved. ABSTRACT Objectives: This study aims to determine the serum levels of interleukin-17A (IL-17A) in children with juvenile idiopathic arthritis (JIA) and analyze the correlation between IL-17A values and disease activity, certain clinical features, and laboratory markers of inflammation. Patients and methods: The study included 30 chil...

2014
Seiichiro Makihara Mitsuhiro Okano Tazuko Fujiwara Yohei Noda Takaya Higaki Tomomi Miyateke Kengo Kanai Takenori Haruna Shin Kariya Kazunori Nishizaki

Interleukin (IL)-17A is a major cytokine produced by Th17 cells, which are associated with chronic inflammations. The local expression of IL-17A in allergic rhinitis (AR) remains to be characterized. We sought to determine the role of IL-17A expression in human inferior turbinate mucosa in the pathophysiology of AR. Inferior turbinate mucosa was sampled from medical treatment-resistant, surgery...

2017
Xiao-Wei Zhang Su Mi Zhe Li Ji-Chao Zhou Jing Xie Fang Hua Ke Li Bing Cui Xiao-Xi Lv Jiao-Jiao Yu Zhuo-Wei Hu

Interleukin-17A has been identified as a driver of hepatic stellate cell activation and plays a critical role in the pathogenesis of hepatic fibrosis. However, the underlining fibrosis-promoting mechanism of IL-17A is far from understood. Here we aimed to define whether hepatocytes directly respond to IL-17A stimulation and are associated with the development of hepatic fibrosis. The functional...

2012
Katsuhisa Ikeda

CONCLUSION Our results demonstrate for the first time a potentially enhanced basal secretion of monocyte chemoattractant protein-1 (MCP-1) and interleukin (IL)-17A-stimulated secretion of IL-6 from nasal polyp fibroblasts, enhanced basal secretion of IL-6 from eosinophilic nasal polyp fibroblasts, and a remarkable up-regulation of IL-9 and granulocyte colony-stimulating factor (G-CSF) from nasa...

2016
Nicola Ivan Lorè Cristina Cigana Camilla Riva Ida De Fino Alessandro Nonis Lorenza Spagnuolo Barbara Sipione Lisa Cariani Daniela Girelli Giacomo Rossi Veronica Basso Carla Colombo Anna Mondino Alessandra Bragonzi

Resistance and tolerance mechanisms participate to the interplay between host and pathogens. IL-17-mediated response has been shown to be crucial for host resistance to respiratory infections, whereas its role in host tolerance during chronic airway colonization is still unclear. Here, we investigated whether IL-17-mediated response modulates mechanisms of host tolerance during airways chronic ...

2014
Nicole L. Ward Dale T. Umetsu

Innate lymphoid cells (ILCs) are a recently discovered family of innate immune cells belonging to the lymphoid lineage, yet lacking antigen-specific receptors. ILCs were first identified in the intestinal tract, where they contribute to epithelial barrier integrity and host responses to commensal microbes. Teunissen et al. (in the current issue) and Villanova et al. (2014) now suggest an import...

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