Interleukin-12 (IL-12) is a heterodimeric 70-kD cytokine that can enhance the activity of cytotoxic effector cells. Although IL-12 shares some functional properties with interleukin-2 (IL-2), it appears to act via a distinct mechanism. In this report, we examined the effects of IL-12 on the cytolytic activity and proliferation of peripheral blood mononuclear cells (PBMC) obtained from patients ...

Bordetella pertussis, the causative agent of whooping cough, possesses an array of virulence factors, including adenylate cyclase toxin (ACT), relevant in the establishment of infection. Here we better define the impact of cyclic AMP (cAMP) intoxication due to the action of ACT on dendritic cell (DC)-driven immune response, by infecting monocyte-derived DC (MDDC) with an ACT-deficient B. pertus...

Background: Based on the reports, Aloe vera extract, a herbal medicine, has antimicrobial and anti-inflammatory effects. Also, this medicinal plant has considerable effects on innate immunity through cytokine secretion which resist fungal infections such as Candida albicans. Moreover, Aloe vera is considered as immunomodulatory agent and regulate inflammatory responses. Materials and Methods: I...

Pemphigus vulgaris (PV) is a chronic autoimmune blistering disease of the skin, in whichloss of adhesion between keratinocytes is caused by autoantibodies. It has been hypothesizedthat cytokines play an essential role in the pathogenesis of PV. This study aimed to investigatethe other immunopathological aspects of PV by determining the serum levels of cytokines inPV patients to find another tre...

purpose the purpose of this study was to examine the effects of ramadan fasting on circulating levels of interleukin-12 (il-12) after a brief maximal exercise. methods nine subjects performed a wingate test on three different occasions: (i) the first week of ramadan (1wr), (ii) the fourth week of ramadan (4wr), and (iii) three weeks after ramadan (ar). blood samples were taken before, immediate...

Abstract Objectives The present study aimed to evaluate interleukin-12 (IL-12) and IL-23 in the saliva of patients with oral lichen planus (OLP) squamous cell carcinoma (SCC). Materials Methods Thirty cases clinical histopathological OLP (bilateral lesions, papular reticular Wickham lines) (Group A), 30 SCCs (OSCCs) B), no history cancer, other or C) were enrolled at Department Oral Medicine Sc...

Objective(s): Interleukin-12 (IL-12) as a cytokine has been proved to have a critical role in stimulating the immune system and has been used as immunotherapeutic agents in cancer gene therapy. Chitosan as a polymer, with high ability of binding to nucleic acids is a good candidate for gene delivery since it is biodegradable, biocompatible and non-allergenic polysaccharide. The objective of the...

Abstract Objective To observe the clinical efficacy of herbal cake-partitioned moxibustion for ulcerative colitis (UC) and elucidate its mechanism by targeting vitamin D receptor (VDR) signaling pathway. Methods A total 63 patients with UC were randomly divided into an observation group (30 cases, treated moxibustion) a control (33 sham moxibustion). Moxibustion treatment was performed at Qihai...