نتایج جستجو برای: interleukin 1β

تعداد نتایج: 105629  

Journal: : 2023

Inflammatory process is at the heart of artificial (artificial) purulent-inflammatory diseases soft tissues (APDST), which may lead to development phlegmon and abscesses site invasion within a three-day period. The study cytokine status rats with APDST allows us evaluate dynamics inflammation markers assess peculiarities pathological course in model inflammation. experiment was carried out on 1...

2015
Bei-lei Ma Pang-Hu Zhou Ting Xie Lei Shi Bo Qiu Qian Wang

BACKGROUND The previous studies indicated that CrmA could ameliorate the interleukin-1β induced osteoarthritis. In this study, we investigated the controlled-released cytokine response modifier A (CrmA) from hyaluronic acid (HA)-chitosan (CS) microspheres to improve interleukin-1β (IL-1β)-stimulated dedifferentiation of chondrocytes. METHODS A rat model of osteoarthritis (OA) in vitro was est...

Journal: :The European respiratory journal 2011
N S Pauwels K R Bracke L L Dupont G R Van Pottelberge S Provoost T Vanden Berghe P Vandenabeele B N Lambrecht G F Joos G G Brusselle

Cigarette smoke (CS), the primary risk factor of chronic obstructive pulmonary disease (COPD), leads to pulmonary inflammation through interleukin-1 receptor (IL-1R)I signalling, as determined using COPD mouse models. It is unclear whether interleukin (IL)-1α or IL-1β, activated by the Nlrp3/caspase-1 axis, is the predominant ligand for IL-1RI in CS-induced responses. We exposed wild-type mice ...

2016
Wanting Shu Ke Mao Qing Gu Lili Yin Xingwei Wu

Native and oxidized (OX) low-density lipoprotein (LDL) may contribute to the pathogenesis of age-related macular degeneration (AMD). In this study, we investigated the effects of lipoproteins, including n-LDL and OX-LDL, on the expression of inflammation factors, interleukin-6 (IL-6) and interleukin-1β (IL-1β), in vivo and in cultured retinal pigment epithelial (RPE) cells. The potential role o...

2009
Cecília Csölle Rómeó D Andó Mária Baranyi József Haller Beáta Sperlágh

Background The P2X7 receptor is a ligand-gated ion channel expressed in neuronal, glial and immune cells and is implicated in a wide range of pathological conditions, including ischemia, and inflammation. The P2X7 receptor can modulate the maturation and release of the proinflammatory cytokine, interleukin-1β (IL-1β). IL-1β is suggested to be involved in the pathophysiology of depression and si...

2013
Miwa Akutsu Naomi Ogura Ko Ito Mutsumi Kawashima Tsuyoshi Kishida Toshirou Kondoh

BACKGROUND Interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) are key mediators of the intracapsular pathological conditions of the temporomandibular joint (TMJ). Therefore, the gene expression profiles in synovial fibroblast-like cells (SFCs) from patients with internal derangement of the TMJ were examined after they were stimulated with IL-1β or TNF-α to determine which genes were alt...

2016
Bo Feng Yangshun Tang Bin Chen Cenglin Xu Yi Wang Yunjian Dai Dengchang Wu Junmin Zhu Shuang Wang Yudong Zhou Liyun Shi Weiwei Hu Xia Zhang Zhong Chen

It remains unclear how infantile febrile seizures (FS) enhance adult seizure susceptibility. Here we showed that the transient increase of interleukin-1β (IL-1β) after prolonged FS promoted adult seizure susceptibility, which was blocked by interleukin-1 receptor antagonist (IL-1Ra) within a critical time window. Postnatal administered IL-1β alone mimicked the effect of FS on adult seizure susc...

2011
Evangelos J Giamarellos-Bourboulis Frank L van de Veerdonk Maria Mouktaroudi Maria Raftogiannis Anastasia Antonopoulou Leo AB Joosten Peter Pickkers Athina Savva Marianna Georgitsi Jos WM van der Meer Mihai G Netea

INTRODUCTION Down-regulation of ex-vivo cytokine production is a specific feature in patients with sepsis. Cytokine downregulation was studied focusing on caspase-1 activation and conversion of pro-interleukin-1β into interleukin-1β (IL-1β). METHODS Peripheral blood mononuclear cells were isolated from a) 92 patients with sepsis mainly of Gram-negative etiology; b) 34 healthy volunteers; and ...

Journal: :American journal of clinical pathology 2014
M Esther San José Lucia Ferreiro M Esther Soneira Francisco J González-Barcala M Carmen Vázquez Antonio Golpe Luis Valdés

OBJECTIVES Thirty percent of patients with pneumonia develop pleural effusion, and of these, 20% have complicated effusion (CPPE), which may require a chest tube or surgery for resolution. The objective of the study is to compare the diagnostic yield of determining interleukin-1β and interleukin-8 in pleural fluid (PF) (PFIL-1β and PFIL-8) with respect to classic criteria (pH <7.2, lactate dehy...

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