نتایج جستجو برای: interferon alfa

تعداد نتایج: 81290  

2010
Wan-Sheng Ke Yuchi Hwang Eugene Lin

Chronic hepatitis C (CHC) patients often stop pursuing interferon-alfa and ribavirin (IFN-alfa/RBV) treatment because of the high cost and associated adverse effects. It is highly desirable, both clinically and economically, to establish tools to distinguish responders from nonresponders and to predict possible outcomes of the IFN-alfa/RBV treatments. Single nucleotide polymorphisms (SNPs) can ...

Journal: :Annals of oncology : official journal of the European Society for Medical Oncology 2008
K Spieth R Kaufmann R Dummer C Garbe J C Becker A Hauschild W Tilgen S Ugurel M Beyeler E B Bröcker K C Kaehler C Pföhler J Gille U Leiter D Schadendorf

BACKGROUND Combination of temozolomide (TMZ) with nonpegylated interferon alfa is associated with increased efficacy in terms of response rates compared with monotherapy. A multicenter phase II study was carried out to assess the activity and toxicity of TMZ plus pegylated interferon alfa-2b (peg-IFNalpha-2b), hypothesizing improved efficacy due to modified pharmacokinetic properties of the nov...

Journal: :Digestion 2008
Ronald Fried Martine Monnat André Seidenberg Robert Oppliger Patrick Schmid Markus Herold Marc Isler Barbara Broers Christoph Kölliker Peter Schönbucher Markus Frei Milo Huber

BACKGROUND Though patients in opiate substitution programs are commonly infected with HCV, due to safety and efficacy concerns, they are rarely treated with interferon and ribavirin. METHODS In a multicenter study, HCV-infected patients in opiate maintenance treatment programs received 180 microg pegylated interferon-alfa-2a once weekly, plus daily ribavirin for 24 weeks (genotypes 2, 3), or ...

Journal: :Gut 1993
C Ferri E Marzo G Longombardo L La Civita F Lombardini D Giuggioli R Vanacore A M Liberati A Mazzoni F Greco

To confirm the positive results of a preliminary trial, 26 patients with mixed cryoglobulinaemia were enrolled in a controlled, randomised, crossover trial with interferon alfa-2b. A significant improvement was seen in the purpura score and alanine aminotransferase activities during six months' treatment, and was associated with a significant decrease in cryocrit and a returning to normal of th...

Journal: :Gut 1996
J Main

Interferon alfa is the only licensed therapy for chronic hepatitis C. The response rate with interferon monotherapy in terms of sustained loss ofHCV RNA is 20-25%. It is now possible to predict, from baseline host and viral factors and from the early response to interferon, which patients are most likely to respond to therapy.' Patients with cirrhosis or type lb infection, for example, are less...

Journal: :Gut 1993
C De Bac F Grimaldi C Clementi F Duca D Livoli G Taliani

Four different dosage regimens of interferon (IFN) alfa-2b (3 million units (MU) three times weekly for three months, 3 MU three times weekly for six months, 6 MU two times weekly for six months, and 6 MU three times weekly for six months) were compared in patients with chronic hepatitis C. There was no significant difference measured by percentage of responders to treatment between the four gr...

Journal: :Revista da Sociedade Brasileira de Medicina Tropical 2012
Ronaldo Soares Martins Juliano Antunes Machado Rosângela Teixeira

The treatment of chronic hepatitis C has frequent side effects such as cytopenias and neuropsychiatric symptoms. However, pulmonary toxicity associated with interferon is rarely described. This paper describes the clinical case of a 67-year-old female patient with chronic hepatitis C who presented an acute onset of dry cough, dyspnoea, and fever 36 weeks after the use of pegylated interferon al...

Journal: :Gut 1993
G L Davis

Early experience with recombinant interferon alfa-2b in chronic hepatitis C (HCV) has shown that normalisation of serum alanine aminotransferase activities and reduction in hepatic inflammation can be achieved in about 40% of patients. This occurs with loss of viral replication as measured by polymerase chain reaction for HCV-RNA. Further studies are needed to identify patients most likely to r...

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