BACKGROUND Do the benefits of intensive lipid-lowering therapy seen in symptomatic patients extend to high-risk subjects who have never had symptoms? METHODS AND RESULTS Of 120 men completing the FATS trial, 91 were symptomatic and 29 asymptomatic. All had apolipoprotein B > or = 125 mg/dL, a positive family history, and coronary atherosclerosis. All were counseled in diet and randomized to i...

IGF binding protein-1 (IGFBP-1), an important regulator of IGF bioavailability, has been shown to correlate with mortality in critically ill patients. In the liver, IGFBP-1 is transcriptionally repressed by insulin, and it is therefore a potential marker of hepatic insulin sensitivity. We have recently shown that, compared with conventional treatment, maintenance of normoglycemia with intensive...

In recent years, intensive care units have been using advanced technology that provides significantly improved results in clinical treatment and care practices. However, this results in intensive care patients experiencing pain and anxiety. This pain and anxiety is generally brought under control with various pharmacological preparations. When a pharmacological approach is not used or is ineffe...

Besser, G. M., et al., British Medical Journal, 1972, 3, 669. 2Friesen, H., and Hwang, P., Annual Review of Medicine, 1973, 24, 251. 3Forbes, A. P., et al., Journal of Clinical Endocrinology and Metabolism, 1954, 14, 265. 4Hafiez, A. A., et al., Journal of Endocrinology, 1972, 52, 327. 5 Boyns, A. R., et al., in Prolactin and Carcinogenesis, ed. A. R. Boyns and K. Griffiths, p. 207. Cardiff, Al...

Severe infections represent the main cause of neonatal mortality accounting for more than one million neonatal deaths worldwide every year. Antibiotics are the most commonly prescribed medications in neonatal intensive care units (NICUs) and in industrialized countries about 1% of neonates are exposed to antibiotic therapy. Sepsis has often nonspecific signs and symptoms and empiric antimicrobi...

Administration of caffeine is global practice in the prevention of apnoea of prematurity. Apnoea leads to hypoxia, bradycardia and cardiovascular instability. It has significant disease burden in this preterm group. Apnoea of prematurity affects 100% of neonates <28 weeks gestation and approximately 50% of infants 30-32 weeks gestational age. Incidence of apnoea is inversely related to gestatio...

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Sufentanil, a potent α-1 agonistic opioid, was synthesized in mid-1970s. It was introduced into clinical practice ten years later, gaining some popularity over the last twenty years. A piperidine derivative, sufentanil has been reported to be 6-10 times more potent than fentanyl, depending on the route of administration; it has been registered for intravenous, epidural and subarachnoid administ...