نتایج جستجو برای: integrins

تعداد نتایج: 15451  

Journal: :European journal of cell biology 2008
Pierre-Jean Wipff Boris Hinz

Integrins are crucial for the ability of cells to sense mechanical perturbations and to transmit intracellular stress to their environment. We here review the more recently discovered role of integrins in activating the pleiotrophic cytokine transforming growth factor beta 1 (TGF-beta1). TGF-beta1 controls tissue homeostasis in embryonic and normal adult tissues and contributes to the developme...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
Moustafa R K Ali Yue Wu Yan Tang Haopeng Xiao Kuangcai Chen Tiegang Han Ning Fang Ronghu Wu Mostafa A El-Sayed

Metastasis is responsible for most cancer-related deaths, but the current clinical treatments are not effective. Recently, gold nanoparticles (AuNPs) were discovered to inhibit cancer cell migration and prevent metastasis. Rationally designed AuNPs could greatly benefit their antimigration property, but the molecular mechanisms need to be explored. Cytoskeletons are cell structural proteins tha...

2017
Marion Lavergne Emily Janus-Bell Mathieu Schaff Christian Gachet Pierre H Mangin

Platelets are small anucleated cell fragments that ensure the arrest of bleeding after a vessel wall injury. They are also involved in non-hemostatic function such as development, immunity, inflammation, and in the hematogeneous phase of metastasis. While the role of platelets in tumor metastasis has been recognized for 60 years, the molecular mechanism underlying this process remains largely u...

Journal: :Journal of cellular biochemistry 2009
Francis J Alenghat Jessica D Tytell Charles K Thodeti Alexandrine Derrien Donald E Ingber

Mechanical stresses that are preferentially transmitted across the cell surface via transmembrane integrin receptors activate gene transcription by triggering production of intracellular chemical second messengers, such as cAMP. Here we show that the sensitivity of the cAMP signaling pathway to mechanical stresses transferred across beta1 integrins is mediated by force-dependent activation of t...

Journal: :Journal of cell science 2011
Shweta Tiwari Janet A Askari Martin J Humphries Neil J Bulleid

Integrins are divalent cation-dependent, αβ heterodimeric adhesion receptors that control many fundamental aspects of cell behaviour by bi-directional signalling between the extracellular matrix and intracellular cytoskeleton. The activation state of cell surface integrins is tightly regulated by divalent cation occupancy of the ligand-binding pocket and by interaction with cytoplasmic adaptor ...

Journal: :Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2005
C Barja-Fidalgo A L J Coelho R Saldanha-Gama E Helal-Neto A Mariano-Oliveira M S de Freitas

Extracellular matrix proteins and cell adhesion receptors (integrins) play essential roles in the regulation of cell adhesion and migration. Interactions of integrins with the extracellular matrix proteins lead to phosphorylation of several intracellular proteins such as focal adhesion kinase, activating different signaling pathways responsible for the regulation of a variety of cell functions,...

Journal: :Journal of cell science 2003
Nancy Hogg Melanie Laschinger Katherine Giles Alison McDowall

T cells use integrins in essentially all of their functions. They use integrins to migrate in and out of lymph nodes and, following infection, to migrate into other tissues. At the beginning of an immune response, integrins also participate in the immunological synapse formed between T cells and antigen-presenting cells. Because the ligands for integrins are widely expressed, integrin activity ...

2017
Dora Maria Cedano Prieto Yushen Cheng Chih-Chieh Chang Jessica Yu Yoko K Takada Yoshikazu Takada

We have reported that integrins crosstalk with growth factors through direct binding to growth factors (e.g., fibroblast growth factor-1, insulin-like growth factor 1 (IGF1), neuregulin-1, fractalkine) and subsequent ternary complex formation with cognate receptor [e.g., integrin/IGF1/IGF1 receptor (IGF1R)]. IGF1 and IGF2 are overexpressed in cancer and major therapeutic targets. We previously ...

Journal: :The Journal of Cell Biology 1999
John D. Loike Long Cao Sadna Budhu Eugene E. Marcantonio Joseph El Khoury Stanley Hoffman Ted A. Yednock Samuel C. Silverstein

Chemoattractants differ in their capacity to stimulate neutrophils to adhere to and to migrate through matrices containing fibrin. Formyl methionyl leucyl phenylalanine (fMLP) stimulates neutrophils to adhere closely to, but not to migrate into, fibrin gels. Leukotriene B4 (LTB4) stimulates neutrophils to adhere loosely to and to migrate through fibrin gels. We report that alpha5beta1 integrins...

Journal: :Development 2002
Richard Grose Caroline Hutter Wilhelm Bloch Irmgard Thorey Fiona M Watt Reinhard Fässler Cord Brakebusch Sabine Werner

Integrins are ubiquitous transmembrane receptors that play crucial roles in cell-cell and cell-matrix interactions. In this study, we have determined the effects of the loss of beta 1 integrins in keratinocytes in vitro and during cutaneous wound repair. Flow cytometry of cultured beta 1-deficient keratinocytes confirmed the absence of beta 1 integrins and showed downregulation of alpha 6 beta ...

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