AIMS/HYPOTHESIS The increasing number of people with dementia and cognitive impairments makes it essential to detect and prevent modifiable risk factors of dementia. This study focuses on type 2 diabetes mellitus, especially on undiagnosed cases and their increased risk of cognitive impairment. Furthermore, the potential of physical activity and social integration to moderate the relation betwe...

OBJECTIVES The objectives were to estimate the prevalence of self-treated hypoglycaemia in patients using basal insulin analogues; identify demographic, treatment related and behavioural risk factors; and describe patient and physician responses to these events. RESEARCH DESIGN AND METHODS The GAPP2 (Global Attitude of Patients and Physicians 2) study was an online multinational cross-section...

Background & Aims: Retinol-binding protein 4 (RBP4) as an adipokine is involved in regulating insulin function and glucose metabolism. Serum levels of RBP4 have been identified as one of the most effective factors in impaired glucose tolerance and diabetes. Studies have shown that exercise improves metabolic syndrome and hepatotoxicity. But the effects of Aqua training on liver Enzymes in diabe...

OBJECTIVE Type 2 diabetes in midlife or late life increases the risk of Alzheimer disease (AD), and type 1 diabetes has been associated with a higher risk of detrimental cognitive outcomes, although studies from older adults are lacking. We investigated whether individuals with AD were more likely to have a history of diabetes than matched controls from the general aged population. RESEARCH D...

OBJECTIVE The purpose of this study was to investigate factors associated with depression in type 1 and type 2 diabetes and test whether these differ from factors associated with depression in the nondiabetic population. RESEARCH DESIGN AND METHODS In an unselected population study comprising 60,869 individuals, potential sociodemographic, lifestyle, and clinical factors were investigated in ...

Currently, there are no national guidelines on transition from paediatric to adult services for children with Type 1 Diabetes Mellitus (T1DM) in Republic of Ireland. There are 19 hospitals in Republic of Ireland looking after children with T1DM. Seventeen have a designated clinic for children with T1DM. Ten have a transition clinic for adolescents with T1DM. Most centres transition after patien...

INTRODUCTION Clinician-led diabetes education is a fundamental component of care to assist people with Type 1 diabetes (T1D) self-manage their disease. Recent initiatives to incorporate a more patient-centered approach to diabetes education have included recommendations to make such education more individualized. Yet there is a dearth of research that identifies patients' perceptions of clinici...

BACKGROUND Surveillance represents a key strategy to control type 1 diabetes mellitus (T1DM). In Italy, national data are missing. This study aimed at evaluating the incidence of T1DM in subjects <18 year olds in Apulia (a large southeastern region, about 4,000,000 inhabitants) and assessing the sensitivity of the regional Registry of Childhood-Onset Diabetes (RCOD) in the 2009-2013 period. M...

OBJECTIVE To assess participant and parent experiences in the parenteral insulin arm of the Diabetes Prevention Trial for Type 1 Diabetes (DPT-1). RESEARCH DESIGN AND METHODS Before trial results were publicized, surveys were completed by 82 intervention participants (the intervention group) (who received annual 4-day insulin infusions and daily insulin injections), 81 closely monitored contr...

OBJECTIVE To examine trends in nontraumatic lower-extremity amputations (LEAs) over an 8-year period in patients with and without diabetes in Spain. RESEARCH DESIGN AND METHODS We identified all patients who underwent an LEA using national hospital discharge data. Discharges were grouped by diabetes status: type 1 diabetes, type 2 diabetes, and no diabetes. The incidence of discharges attribu...