The sigma-receptor, a broadly distributed integral membrane protein with a novel structure, is known to modulate various voltage-gated K(+) and Ca(2+) channels through a mechanism that involves neither G proteins nor phosphorylation. The present study investigated the modulation of the heart voltage-gated Na(+) channel (Na(v)1.5) by sigma-receptors. The sigma(1)-receptor ligands [SKF-10047 and ...

 In Proposition 2.6 in (G‎. ‎Gruenhage‎, ‎A‎. ‎Lutzer‎, ‎Baire and Volterra spaces‎, ‎textit{Proc‎. ‎Amer‎. ‎Math‎. ‎Soc.} {128} (2000)‎, ‎no‎. ‎10‎, ‎3115--3124) a condition that‎ ‎every point of $D$ is $G_delta$ in $X$ was overlooked‎. ‎So we‎ ‎proved some conditions by which a Baire space is equivalent to a‎ ‎Volterra space‎. ‎In this note we show that if $X$ is a‎ ‎monotonically normal $T_1...

recent developments in medicine have given us a better insight into a group of disorders known as autoimmune diseases. in particular, advances have occurred in our understanding of the autoimmune inner ear disease (aied). in this article, the authors review the different postulated theories in the pathogenesis of this disease. the clinical presentation, the available para-clinical diagnostic to...

Bacterial sigma (sigma) factors are an essential component of RNA polymerase and determine promoter selectivity. The substitution of one sigma factor for another can redirect some or all of the RNA polymerase in a cell to activate the transcription of genes that would otherwise be silent. As a class, alternative sigma factors play key roles in coordinating gene transcription during various stre...

We model the near infrared SED of NGC 4151 with a 3-D radiative transfer SKIRT code, using which torus only (TO) and Ring And Torus (RAT) scenarios are studied. In RAT models, graphite ring-like structure (clumpy or smooth), is incorporated between accretion disk. vary inclination angle $(i)$, inner radius (of ring, $R_{\rm in, t}$ r}$ respectively), half-opening ($\sigma $), optical depth ($\t...

Cruz Biotechnology), anti-FLAG (M2; Sigma Chemical Co., St. Louis, MO), anti-β-actin (AC-15; Sigma), and anti-α-tubulin (B-5-1-2; Sigma Chemical Co.) were used. Anti-Synoviolin monoclonal antibody (10Da) was reported previously (Amano et al., 2003). Cycloheximide (Sigma Chemical Co., 100μg/mL) was used for the chase experiment of p53. Camptothecine (Sigma, 0.5 mM), and actinomycin D (Sigma Chem...

studies pertaining convergence and its benefits for developing and underdeveloped countries, specifically latin american countries and the caribbean islands are essential because they can create the necessary grounds for further growth and development. the aim of this study is to analyze the economic growth of latin american countries and the caribbeans after their beta and sigma convergences d...