نتایج جستجو برای: inner ear malformation
تعداد نتایج: 127724 فیلتر نتایج به سال:
Spontaneous cerebrospinal fluid (CSF) fistula in congenital malformations of the inner ear is rare, and it is found most commonly in infants and children with impaired hearing. Spontaneous CSF otorrhea in adults is often due to defects in the tegmen and the bone overlying the posterior fossa in an otherwise normal ear. In the literature, there are few reports of adultonset spontaneous CSF otorr...
(Edmonds C. Inner ear barotrauma: a retrospective clinical series of 50 cases. SPUMS J. 2004; 34: 11-4.) A retrospective series of 50 cases of inner ear barotrauma is reviewed, as regards the diving and otological history, the clinical manifestations, basic audiometric investigations and treatments. This disorder may be predicted to some degree by a previous history of otological barotraumas, o...
The Auditory Brainstem Implant (ABI) is based on the classic cochlear implant (CI) but uses a different stimulation electrode. At MED-EL, early development activities ABI started in year 1994, with suggestion coming from J. Helms and Müller Würzburg, Germany collaboration Univ. of Innsbruck Austria. first surgery neuro-fibromatosis (NF2) patient MED-EL device took place 1997. Later, indication ...
The elongation and contraction of outer hair cells (OHCs) greatly contribute to the high sensitivity and frequency selectivity of the mammalian inner ear. The motility of OHCs is believed to be based on the conformational changes of the motor protein prestin in the plasma membrane of OHCs. In the present study, four lines of research on the inner ear were conducted. First, the mechanism by whic...
kreisler is a recessive mutation resulting in gross malformation of the inner ear of homozygous mice. The defects in the inner ear are related to abnormalities in the hindbrain of the embryo, adjacent to the ear rudiments. At E9.5, the neural tube posterior to the boundary between the third and fourth rhombomeres, r3 and r4, appears unsegmented, and the region that would normally correspond to ...
Autoimmunity is thought to be one cause of sensorineural hearing loss (SNHL). Sera from patients with rapidly progressive hearing loss have been shown to contain antibodies to a 68-kD protein in heterologous inner-ear tissue. Using guinea pig inner-ear tissue as the antigenic substrate and either Western blot or immunofluorescence (IF) or both, we tested sera from 74 patients suspected to have ...
In accordance with longstanding convention, the adult ear is here described in terms of its three portions, namely the outer, the middle and the inner ear. The inner ear, comprising the bony and membranous labyrinth with its central connections, arises from a set of structures quite distinct from those which give rise to the outer and middle ears. The development of the inner ear, which is the ...
In vertebrates, the inner ear arises from the otic placode, a thickened swathe of ectoderm that invaginates to form the otic vesicle. We report that histone demethylase KDM4B is dynamically expressed during early stages of chick inner ear formation. A loss of KDM4B results in defective invagination and striking morphological changes in the otic epithelium, characterized by abnormal localization...
In this review the authors discuss the physiopathologic and electrophysiologic changes of the inner ear in Meniere's disease, otosclerosis, ototoxicity, acoustic neuroma, presbycusis, noise-induced hearing loss, metabolic hearing loss, perilymphatic fistula, syphilis, autoimmune inner ear disease, congenital genetic hearing loss, and viral labyrinthitis. The etiology and pathogenesis of hearing...
Gfi1 was first identified as causing interleukin 2-independent growth in T cells and lymphomagenesis in mice. Much work has shown that Gfi1 and Gfi1b, a second mouse homolog, play pivotal roles in blood cell lineage differentiation. However, neither Gfi1 nor Gfi1b has been implicated in nervous system development, even though their invertebrate homologues, senseless in Drosophila and pag-3 in C...
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