نتایج جستجو برای: innate immune system

تعداد نتایج: 2443056  

Journal: :Fish & shellfish immunology 2006
Bergljót Magnadóttir

The innate immune system is the only defence weapon of invertebrates and a fundamental defence mechanism of fish. The innate system also plays an instructive role in the acquired immune response and homeostasis and is therefore equally important in higher vertebrates. The innate system's recognition of non-self and danger signals is served by a limited number of germ-line encoded pattern recogn...

Abolfazl Barzegar Bafrouei, Elham karimipour, Moosa Javdani,

A part of the immune system that improves (complements) the ability of antibodies and phagocytic cells to clear microorganisms and injured cells from an organism, attacks the pathogen's cell membrane, and encourages inflammation called complement system. It is main part of immune system. Over thirty proteins and protein pieces compose the complement system, including cell membrane receptors, an...

2012
Clare E. Bryant Tom P. Monie

The innate immune response is the first line of defence against infection. Germ-line-encoded receptors recognize conserved molecular motifs from both exogenous and endogenous sources. Receptor activation results in the initiation of a pro-inflammatory immune response that enables the resolution of infection. Understanding the inner workings of the innate immune system is a fundamental requireme...

Journal: :Journal of innate immunity 2011
Laura Maintz Natalija Novak

Atopic dermatitis (AD) is a frequent chronic inflammatory skin disease which is often complicated by recurrent microbial superinfections. Genetically based modifications which might have an impact on the innate immune system, such as impairment of the skin barrier, modifications of pattern recognition receptors, deficiency of antimicrobial peptides, antiviral natural killer cells and plasmacyto...

2011
Richard Warrington Wade Watson Harold L Kim Francesca Romana Antonetti

In basic terms, the immune system has two lines of defense: innate immunity and adaptive immunity. Innate immunity is the first immunological, non-specific (antigen-independent) mechanism for fighting against an intruding pathogen. It is a rapid immune response, occurring within minutes or hours after aggression, that has no immunologic memory. Adaptive immunity, on the other hand, is antigen-d...

2017
Cheng-Liang Yang Jun Wang Li-Li Zou

As an infectious fungus that affects the respiratory tract, Cryptococcus neoformans (C. neoformans) commonly causes asymptomatic pulmonary infection. C. neoformans may target the brain instead of the lungs and cross the blood-brain barrier (BBB) in the early phase of infection; however, this is dependent on successful evasion of the host innate immune system. During the initial stage of fungal ...

Journal: :Advances in experimental medicine and biology 2012
Beatriz Novoa Antonio Figueras

The zebrafish (Danio rerio) has been extensively used in biomedical research as a model to study vertebrate development and hematopoiesis and recently, it has been adopted into varied fields including immunology. After fertilization, larvae survive with only the innate immune responses because adaptive immune system is morphologically and functionally mature only after 4-6 weeks postfertilizati...

2013
Cameron G. McCarthy Styliani Goulopoulou Camilla F. Wenceslau Kathryn Spitler Takayuki Matsumoto Clinton Webb

McCarthy CG, Goulopoulou S, Wenceslau CF, Spitler K, Matsumoto T, Webb RC. Toll-like receptors and damage-associated molecular patterns: novel links between inflammation and hypertension. Am J Physiol Heart Circ Physiol 306: H184–H196, 2014. First published October 25, 2013; doi:10.1152/ajpheart.00328.2013.—Low-grade systemic inflammation is a common manifestation of hypertension; however, the ...

Journal: :Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2012
D Hartl A Gaggar E Bruscia A Hector V Marcos A Jung C Greene G McElvaney M Mall G Döring

Chronic lung disease determines the morbidity and mortality of cystic fibrosis (CF) patients. The pulmonary immune response in CF is characterized by an early and non-resolving activation of the innate immune system, which is dysregulated at several levels. Here we provide a comprehensive overview of innate immunity in CF lung disease, involving (i) epithelial dysfunction, (ii) pathogen sensing...

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