The intraovarian function of gonadally produced inhibin and activin has been extensively studied in experimental models for decades, yet their presence and function have been rarely reported in wild rodents. With our seasonal breeding model, the wild ground squirrel, we aimed to investigate the possible roles of these peptides in the seasonal folliculogenesis. Immunohistochemical staining and W...

OBJECTIVE To examine whether obesity and insulin resistance have an independent effect on the gonadotropin, estradiol, and inhibin B serum levels and follicle count in the early follicular phase of fertile women with a wide range of BMI and without signs of hyperandrogenism. RESEARCH METHODS AND PROCEDURES Twenty-two overweight and obese (BMI > or =25.0 kg/m(2)) women and 10 normal-weight (BM...

BACKGROUND The aim of this study was to investigate the predictive accuracy and clinical value of performing either a single or a repeated clomiphene citrate challenge test (CCCT) in predicting poor response in IVF, compared to that of currently used basal ovarian reserve markers. METHODS Sixty-three patients undergoing their first IVF treatment were prospectively included. After measurement ...

Premature menopause and unexplained infertility are associated with ovarian antibodies, a marker of ovarian autoimmunity. In premature menopause, FSH is also elevated while in unexplained infertility FSH concentrations are often normal. The relationship of ovarian antibodies and FSH and inhibin B, as markers of follicle function, was investigated in unexplained infertility. Ovarian antibodies w...

OBJECTIVE To investigate whether the prevention of early follicular growth by luteal E(2) administration improves the relationship between day 3 hormone measurements and the ovarian follicular status. DESIGN Prospective, cohort study. SETTING Assisted reproductive technology unit in Clamart, France. PATIENT(S) One hundred sixty-two infertile women. INTERVENTION(S) Participants received ...

INTRODUCTION To study the impact on adult's fertility of serum inhibin B levels in adolescent patients with idiopathic varicocele after minimally invasive surgical correction and to compare fluctuation of pituitary-testis hormonal values and testicular volumes. MATERIALS AND METHODS A case-control study was carried out on a group adolescent patients (n=60) affected by idiopathic left varicoce...

197 words): Animal experiments and some human studies indicate that PBDEs may adversely affect male reproductive function. We collected three serum samples from 27 healthy adult men at 6-month intervals in the FlaRE study and assessed associations between PBDE exposure and reproductive function tests using mixed effects regression models, adjusting for confounders. Geometric mean concentrations...

At present, there is no reliable in vitro assembled prepubertal testis-like biomimetic organ culture system designed to assess the functional effects of human gonadotropins on Sertoli and Leydig cells. Spermatogenesis is regulated by endocrine, paracrine, and juxtacrine factors (testicular cross-talk), mainly orchestrated by gonadotropins such as luteinizing hormone (LH) and follicle-stimulatin...

OBJECTIVE Open testicular biopsy (OTB) is one of the options to accurately assess fertility potential of the undescended testis. The aim of the study was to investigate consequences of OTB in prepubertal rats on their adulthood fertility. METHODS Thirty-eight prepubertal male rats were divided into three groups depending on day 20 procedure. The first group was the control group, the second s...