UNLABELLED Theme: Complex health care and chronic disease management. INTRODUCTION Congenital heart disease (CHD) may have a very important impact on central nervous system function and neurodevelopment. PURPOSE Critical evaluation of literature concerning the neurodevelopmental outcomes following congenital heart surgery. METHODS Systematic review of 28 articles published after 2000 in P...

Introduction:Neurofibromatosis is a genetic disease characterized by multifocal benign tumors of peripheral nerves, called neurofibromas, and pigmented spots on the skin which inherited as autosomal-dominant. The most common form of the disease is neurofibromatosis type 1, also known as von Recklinghausen's disease of the skin. When an individual has small number of lesions in a limited region ...

Arrhythmogenic cardiomyopathy (ACM) is an inherited multifaceted cardiac disease that causes sudden death, especially in young adults and athletes [...]

Most of our current knowledge about cellular phenotypes in neurodevelopmental and neurodegenerative diseases in humans was gathered from studies in postmortem brain tissues. These samples often represent the end-stage of the disease and therefore are not always a fair representation of how the disease developed. Moreover, under these circumstances, the pathology observed could be a secondary ef...

Polycystic kidney disease is a multisystemic familial inherited disease. A symptomatic treatment approach the standard modality for autosomal dominant polycystic (ADPKD) complications and life-long 50% chronic renal failure risk, as transplantation only definitive treatment.