Immune reconstitution inflammatory syndrome (IRIS) in the setting of antiretroviral therapy is well described, but it is not as common in non-HIV patients; here, we present a case of immune reconstitution inflammatory syndrome presenting as acute respiratory distress syndrome in a leukemia patient who had neutropenic fever and septic shock after high-dose cytarabine. During neutropenia recovery...

It has been established that some nonsteroidal anti-inflammatory drugs (NSAIDs) when administered through injectable preparations have a local irritating effect, even though the are considered high-quality. seems this irritant action is not related to any specific pharmacological but with physicochemical properties of preparation grossly violate homeostasis tissues. complications at injection s...

Sepsis is a life-threatening organ dysfunction caused by disturbed response to infection. The development of sepsis preceded Systemic Inflammatory Response Syndrome (SIRS), which the overall inflammatory body severe lesion. role opportunistic pathogens in CER and may be considered proven, but value intestinal microbiome remains underestimated. survey systematized data on cell wall or membrane c...

A randomised controlled study: efficacy of ICU nursing risk management combined with the cluster model and its effect on quality life inflammatory factor levels patients acute respiratory distress syndrome ventilator-associated pneumonia

Background CAPS encompasses a spectrum of three phenotypes: familial cold auto-inflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), and chronic infantile neurologic cutaneous and articular syndrome/neonatal onset multisystem inflammatory disease (CINCA/ NOMID)[1]. The b-Confident Registry, the largest CAPS cohort documented in a registry, enrolled the last patient in December 2014. Here, ...

Inflammatory and immune-mediated polyneuropathies represent an important differential diagnosis of hereditary and acquired polyneuropathies. In this article, we will provide you with all the relevant facts concerning the GuillainBarré syndrome, the Miller-Fisher syndrome, and the Elsberg syndrome. Also, we will cover the chronic-inflammatory demyelinating polyneuropathy (CIDP) and multifocal mo...

Abstract Inflammatory cytokine storm is a known cause for acute respiratory distress syndrome. In this study, we have investigated the role of IFN-γ in lethal lung inflammation using mouse model postinfluenza methicillin-resistant Staphylococcus aureus (MRSA) pneumonia. To mimic clinical scenario, animals were treated with antibiotics effective bacterial control following MRSA superinfection. H...

Blau syndrome is a rare autosomal dominant autoinflammatory granulomatous disease caused by the mutation in NOD2 gene and characterized clinical triad of dermatitis, arthritis, uveitis. Since efficacy Janus kinase inhibitors (JAKi) has recently been reported for addition to idiopathic sarcoidosis, we evaluate effect tofacitinib, pan JAKi, on inflammatory pathways associated with syndrome. First...

Immune reconstitution inflammatory syndrome can present as a paradoxical reaction after initiation of antiretroviral treatment in patients with severe immunosuppression and underlying infections. Immune reconstitution inflammatory syndrome has often been associated with mycobacteria, and the clinical response to traditional treatment with corticosteroids is not always satisfactory. Consequently...

Sweet syndrome is a cutaneous lesion characterized by tender, red inflammatory nodules or papules. We describe a pediatric case of Sweet syndrome presenting 10 days after treatment with azathioprine. As azathioprine is widely used in children with inflammatory bowel disease, clinicians should be aware of this unusual adverse reaction.