نتایج جستجو برای: inflammatory proteins
تعداد نتایج: 794929 فیلتر نتایج به سال:
OBJECTIVE Genetic and immunological data indicate that inflammatory bowel disease (IBD) are characterized by specific inflammatory protein profiles. However, the serum proteome of IBD is still to be defined. We aimed to characterize the inflammatory serum protein profiles of Crohn's disease (CD) and ulcerative colitis (UC), using the novel proximity extension assay. METHODS A panel of 91 infl...
Myeloid-related protein 8 (MRP8) and MRP14, S100 proteins secreted by activated phagocytes, bind specifically to endothelial cells. The endothelial response to MRP8/MRP14, however, is unknown. Using oligonucleotide microarray analysis, we show for the first time that MRP8/MRP14 induce a thrombogenic, inflammatory response in human microvascular endothelial cells by increasing the transcription ...
A dsRNA detector in the immune toolkit Nod-like receptor (NLR) proteins recognize pathogen-associated molecular patterns within cells, which triggers formation of signaling complexes called inflammasomes. These then initiate pyroptosis, a highly inflammatory form cell death. Recent work has shown that rhinovirus protease can activate human NLRP1 inflammasome, but it was unclear whether this is ...
p 59: non-steroidal anti-inflammatory drugs as a prevention of alzheimer disease: risks and benefits
alzheimer's disease (ad) is a chronic neurodegenerative disease that accounts for 60 to 80 percent of all dementia cases. the exact cause of alzheimer`s disease is still unknown, but recent studies suggest neuro-inflammation as an important part of the pathogenesis of the disease. this brings in mind using non-steroidal anti-inflammatory drugs (nsaid) as treatment or prevention of the dise...
Background: Inflammatory processes relying on intrahepatic neutrophil accumulation predominate the priming phase of liver regeneration. During later stages relevance neutrophils remains incompletely understood. Here we aimed to investigate dynamic phenotypical changes circulating upon stimulation with apoptotic cell derived extracellular vesicles (aEV) and their potential role in human Methods:...
Adipose tissue serves as an energy store and is also active endocrine organ, exerting activity that influences obesity-related processes through the production of regulatory proteins called adipokines or adipocytokines. Adipokines play important direct indirect roles in pathogenesis insulin resistance, regulation local systemic inflammatory processes, related metabolic complications. There have...
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