The relationship between penile lichen sclerosus (LS) and cancer development has not been clearly assessed so far. In order to define these histological features of LS that may indicate or precede a malignant degeneration, 104 biopsy specimens from 86 patients with LS of the glans (90.5%) and from 9 patients with a penile malignancy (7 squamous cell carcinomas, 1 in situ carcinoma, and 1 verruc...

PURPOSE To investigate the effect of chronic experimental diabetes on skin allografts in rats as a simple model that could clarify some basic aspects and mechanisms involved in transplant rejection in diabetes compared to normal animals. METHODS Skin grafting was performed with fragments of tail skin from sex matched non diabetic Wistar rats engrafted onto the thoracic area of diabetic and no...

The rapid disappearance of infective forms of Trypanosoma cruzi from the site of inoculation as well as the initial phase of infection produced by the parasite are not yet fully understood. To investigate this problem we used the hamster as an animal model considering the existence of the cheek pouch--a peculiar region devoid of lymphatic vessels. T. cruzi trypomastigotes were inoculated into t...

5 Correspondence: Roxana Duda 1 Calistrat Grozovici Str., 2 District, Bucharest, Romania e-mail: [email protected] Abstract. Introduction. Chronic rhinosinusitis with nasal polyposis is an important and complex disease characterized by a persistent inflammatory process involving the sinonasal mucosa, representing a serious health problem and economic challenge, with pathogenic mechanisms st...

The objective of this study was to evaluate the expression of matrix metalloproteinase 9 (MMP-9) and transforming growth factor beta (TGF-β1) in periapical lesion samples correlated with the intensity of the inflammatory infiltrate and thickness of the epithelial lining. Forty-five cases of periapical lesions (23 periapical granulomas and 22 radicular cysts) were subjected to morphological and ...

Adipokines, cytokines mainly produced by adipocytes, are active participants in the regulation of inflammation. Administration of zymosan (ZY) was used to investigate the regulation and role of adipokines during peritonitis in mice. Injection of ZY led to a significant increase in leptin levels in both serum and peritoneal lavage fluid, whereas a differential trend in local vs. systemic levels ...

OBJECTIVE To research technical alternatives for permanent gastrostomy that minimizes the drawbacks and complications reported by several authors. MATERIALS AND METHODS An experimental model was developed where the material was divided into 2 groups: the study group (SG) composed of 12 half-breed dogs where the proposed technique was applied, and the control group (CG) composed of 10 animals ...